Bioequivalence and Bioavailability Forum

complete or not [Study As­sess­ment]

posted by Helmut  – Vienna, Austria, 2016-05-24 14:57  – Posting: # 16361
Views: 18,124

Dear Detlew,

» » My preference is REML/Satterthwaite because one could reproduce results in three different software packages.
» Emphasis by me.
»
» That's not really a reason.

I stand corrected.

» The first sentences seem to point to an advantage of REML over ML estimation, left the question of the ddfm aside.

Yep. In dose proportionality quite often (much) more levels than in BE come into play. The highest I have seen so far were five. Unbalanced & incomplete data are more the rule than an exception. That’s why I would prefer REML.

—
Cheers,
Helmut Schütz


The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

• Dose Proportionality and Variance AngusMcLean 2016-05-11 16:55 [Study As­sess­ment] 
  • More information, please Helmut 2016-05-12 14:34
    • More information, please AngusMcLean 2016-05-13 16:40
      • Setup in Phoenix/WinNonlin Helmut 2016-05-14 02:26
        • Setup in Phoenix/WinNonlin AngusMcLean 2016-05-14 18:54
          • Setup in Phoenix/WinNonlin Helmut 2016-05-15 14:47
            • Setup in Phoenix/WinNonlin AngusMcLean 2016-05-15 15:17
              • Phoenix 64 Warning Helmut 2016-05-15 15:56
                • Phoenix 64 Warning AngusMcLean 2016-05-15 20:11
                  • OT: imperial vs. metric units Helmut 2016-05-16 16:26
              • Setup in Phoenix/WinNonlin ElMaestro 2016-05-15 20:54
                • Setup in Phoenix/WinNonlin AngusMcLean 2016-05-15 22:30
        • Setup in Phoenix/WinNonlin AngusMcLean 2016-05-16 21:00
          • NCSS vs. PHX/WNL vs. SAS Helmut 2016-05-17 01:50
            • NCSS vs. PHX/WNL vs. SAS - Validation? mittyri 2016-05-18 08:23
              • Diagnostics ElMaestro 2016-05-18 09:20
                • Diagnostics: R and Phoenix Helmut 2016-05-18 15:14
                  • Diagnostics: R zizou 2016-05-22 19:07
                    • Diagnostics: R Helmut 2016-05-23 01:22
                      • SASian potpourri d_labes 2016-05-24 12:02
                        • Compilation Helmut 2016-05-24 14:27
                          • REML or not d_labes 2016-05-24 16:33
                            • complete or notHelmut 2016-05-24 16:57
                          • Compilation AngusMcLean 2016-05-26 16:46
                            • doubts about NCSS Helmut 2016-05-26 19:13
                              • Doubts about NCSS zizou 2016-05-26 23:38
                          • Compilation AngusMcLean 2016-05-28 00:51
                            • Kenward-Roger? Helmut 2016-05-28 15:59
                          • 90% confidence interval for R_dnm Shuanghe 2019-01-04 17:45
                            • 90% confidence interval for R_dnm d_labes 2019-01-05 14:01
                              • Visualizing lmer and limits mittyri 2019-01-06 17:00
                                • Visualizing lmer and limits Shuanghe 2019-01-07 11:05
                                • Visualizing lmer and limits d_labes 2019-01-07 15:08
                                  • Visualizing lmer and limits mittyri 2019-01-13 23:53
                              • 90% confidence interval for R_dnm Shuanghe 2019-01-07 10:53
                                • 90% confidence interval for R_dnm d_labes 2019-01-07 15:17
                                  • 90% confidence interval for R_dnm Shuanghe 2019-01-07 17:11
                                    • 90% confidence interval for R_dnm d_labes 2019-01-07 18:24
                                    • offtop: greek letters and tables mittyri 2019-01-08 00:19
                                      • OT: greek letters and symbols Helmut 2019-02-02 16:04
              • Smith’s paper Helmut 2016-05-18 14:44
                • Smith’s paper d_labes 2019-01-05 15:00