Bioequivalence and Bioavailability Forum

Subject	Category	Author	posted	Replies	last R.	Views
⚠️ Read before registering 📌	Tips / Tricks	Helmut	2016-04-14 23:39	0		109,710
Matrix effect during study sample analysis Matrix effect during study sample analysis Matrix effect during study sample analysis Matrix effect during study sample analysis Matrix effect during study sample analysis	Bioanalytics	shreyas goswami	2020-04-09 08:18	4	2020-04-10 17:29	100
Missing periods in replicate designs Missing periods in replicate designs Missing samples Missing ambulatory samples Missing ambulatory samples Missing ambulatory samples Missing periods in replicate designs Missing periods in replicate designs Missing periods in replicate designs Missing periods in replicate designs Missing periods in replicate designs: save the data? Missing periods in replicate designs: save the data? Missing periods in replicate designs: kill the data? Meaningful data? Missing periods in replicate designs Kenward-Roger? Kenward-Roger? Kenward-Roger ≥ Satterthwaite Kenward-Roger ≥ Satterthwaite Kenward-Roger - links Kenward-Roger - links degrees of freedom degrees of freedom	RSABE / ABEL	Helmut	2019-10-16 13:14	22	2020-04-09 16:54	2,402
updates of installation bear with macOS (Mojave) upgrade R with macOS (Mojave) an old itch when running RGtk2 (GUI) with macOS upgrade/re-install cairoDevice package from source (macOS) updates of installation bear with macOS (Mojave) bear with Catalina OS	R for BE/BA	yjlee168	2019-07-08 10:15	5	2020-04-09 15:46	1,859
randomization randomization randomization randomization package randomizeBE for R on steroids Randomization of gender Simplified R-code Simplified R-code Updated R-code Gender in crossover Gender in crossover Sex in crossover Sex in crossover OT: Sex / gender OT: Sex / gender OT: Sex / gender Updated R-code	R for BE/BA	Ana Cristina	2018-02-23 21:33	16	2020-04-08 12:31	8,150
Tegaserod analytical method	Regulatives / Guidelines	Ayman Rabayah	2020-04-08 11:23	0		57
Meets primary objective but not secondary objective Meets primary objective but not secondary objective Meets primary objective but not secondary objective Meets primary objective but not secondary objective Meets primary objective but not secondary objective	Study Assessment	Brus	2020-03-27 17:22	4	2020-04-06 19:41	275
Claim of Categorical Exclusion (21 CFR)	Regulatives / Guidelines	ping4santosh	2020-04-06 13:55	0		64
Dissolution and bracketing - EMA Dissolution and bracketing - EMA Dissolution and bracketing Dissolution and bracketing Dissolution and bracketing (EMA)	Regulatives / Guidelines	Susanh	2020-03-19 18:39	4	2020-04-04 08:42	1,642
Statistical evaluation and BE hypotheses in full replicate design Inflation of the TIE as well Inflation of the TIE as well Tricky… Tricky… Terrible… Tricky… Deep shit Deep shit Deep shit Deep shit Deep shit Deep shit Deep shit Flawed evaluation accepted Flawed evaluation accepted Flawed evaluation accepted Flawed evaluation accepted Flawed approach even if accepted 😡 Flawed approach even if accepted 😡 misunderstanding misunderstanding misunderstanding The globe is flat! Tricky… Tricky… Tricky… ABE vs. ABEL zigzag zigzag zigzag helter-skelter helter-skelter Inflation of the TIE as well Inflation of the TIE as well Inflation of the TIE as well Fishing in the dark Statistical evaluation and BE hypotheses in full replicate design TIE, repeat once more please...	RSABE / ABEL	Elena777	2020-01-28 07:02	38	2020-04-02 12:41	10,536
Bonferroni and Bartlet's tests	Study Performance	Achievwin	2020-03-31 21:37	0		120
Impact of COVID-19 on HV trials Impact of COVID-19 on HV trials Impact of COVID-19 on HV trials Impact of COVID-19 on HV trials	Study Performance	Laura R	2020-03-22 08:58	3	2020-03-31 03:09	1,372
Clinical trials in Corona (Covid-19) time. What I am missing.... What I am missing....	Regulatives / Guidelines	wienui	2020-03-29 07:15	2	2020-03-29 09:26	276
MR generic application MR generic application MR generic application MR generic application	Regulatives / Guidelines	Mikkabel	2020-03-16 16:40	3	2020-03-27 21:20	2,246
Steady State Bioequivalence Study Pre-dose samples Study design multiple dose stuy - circadian PK	Design Issues	Pharma_88	2020-01-08 10:07	2	2020-03-26 17:29	2,827