Bioequivalence and Bioavailability Forum

Subject	Author	posted	Replies	last R.	Views
Fantastic PK parameters and where to find them Fantastic post 👍🏽 Rattleback Chatter Reinventing the Hula-Hoop Hula-Hoop references Prof. Keller vs. Yamaoka SHAM(e) math SHAM(e) math OT: Möbius strip OT: Möbius strip More stuff MRT and Gravity duration Fantastic PK parameters and where to find them Cauchy distribution Cauchy distribution Cauchy distribution noncentral normal ratio	Astea	2020-06-12 14:22	17	2020-06-24 11:29	2,295
BLQ handling in BE study where all values in one profile are BLQ BLQ handling in BE study where all values in one profile are BLQ all values in one profile are BLQ (test) BLQ handling in BE study where all values in one profile are BLQ BLQ handling in BE study where all values in one profile are BLQ	Hutchy_7	2019-11-28 15:17	4	2019-11-28 17:44	2,262
“Average” plots “Average” plots “Average” plots Three shades of red Three shades of red Three shades of red Three shades of red	Helmut	2019-04-25 19:06	6	2019-04-26 18:27	2,360
Metrics for absorption Metrics for absorption Metrics for absorption Metrics for absorption Metrics for absorption Metrics for absorption Metrics for absorption Metrics for absorption Metrics for absorption Metrics for absorption Metrics for absorption Simulation framework Simulation framework Conclusion Conclusion & beyond	Helmut	2019-04-15 12:08	14	2019-04-17 17:05	3,904
AUC0-tau at steady state AUC0-tau at steady state AUC0-tau at steady state RTFM RTFM AUC0-τ estimation with time deviations AUC0-τ estimation with time deviations Cτ for lin and lin-up/log-down Cτ by lin-/lin, lin-up/log-down, and λz inter- vs extra- inter- vs extra- No rule fits all one size fits all vs goal posts one size fits all vs goal posts Bias etc. software: NCA not validated no way out for NCA validation? Default rules	BNR	2016-03-31 22:46	17	2019-02-20 21:40	10,276
Steady state: Cmin / PTF Steady state: Cmin / PTF Steady state: Cmin / PTF Is Cmin an atavism or not? Originators \| generics (Cmin \| Cτ) Down with Big Brother Down with Big Brother thoughtcrime blackwhite animal farm	Helmut	2011-03-08 15:30	9	2019-02-04 15:53	9,258
Baseline correction method Baseline correction method Baseline correction method	Sundar.M	2019-01-07 13:54	2	2019-01-08 17:42	1,636
Exclusion of PK parameters where less than 3 quantifiable concentrations Reliable estimates?	Babe_Ruth	2018-06-19 18:13	1	2018-06-20 01:12	1,668
PK parameters Good reporting practices	lakshmiprasad	2018-05-17 06:55	1	2018-05-17 13:20	1,655
half-life in multiple-dosed steady-state BE/BA study? half-life in steady state; WinNonlin no lambda(z), no NCA? NCA without lambda(z) No rule is the rule - lambda(z) of MD BE Distinguish accumulation	yjlee168	2009-07-14 14:16	5	2018-01-05 00:10	12,916
calculation of cutoff time point in case of multiphasic modified release cutoff time point based on PK? cutoff time point based on PK?	Biostats	2017-11-25 09:22	2	2017-11-26 07:36	2,357
BLLOQ (or NQ-Non Quantifiable Concentrations) in PK Concentration data	Ashwitha	2017-07-09 15:02	0		1,650
Calculation of AUC0-72 Calculation of AUC0-72 Calculation of AUC0-72 Calculation of AUC0-72 Regulators truncated Regulators truncated Regulators truncated Regulators truncated Regulators truncated Regulators truncated Regulators truncated Luke 23:34 Calculation of AUC0-72 Calculation of AUC0-72 Calculation of AUC0-72 Calculation of AUC0-72 The missing 72h The missing 72h sensitivity analyses ? Regulators ways are inscrutable Regulators ways are inscrutable (at least the French) The missing 72h Page 3848 of 221 Partial AUC calculation Partial AUC calculation	Sasi	2008-06-10 10:44	24	2017-03-16 19:46	22,283
Which Tmax to be consider in case of b.i.d. dosing? Which Tmax to be consider in case of b.i.d. dosing? Which Tmax to be consider in case of b.i.d. dosing? Which Tmax to be consider in case of b.i.d. dosing? Which Tmax to be consider in case of b.i.d. dosing?	maulik963	2016-04-13 08:06	4	2016-04-16 12:32	4,057
0.00 concentration value between two measurable concentrations 0.00 concentration value between two measurable concentrations “Embedded BQLs” “Embedded BQLs”	arl_stat	2016-03-02 10:13	3	2016-04-15 08:50	4,470