Bioequivalence and Bioavailability Forum 15:26 CET

Main page Policy/Terms of Use Abbreviations Latest Posts

 Log in |  Register |  Search

“Forced BE” 101 [Power / Sample Size]

posted by kms.srinivas - India, 2017-12-27 12:41  - Posting: # 18098
Views: 12,037

(edited by kms.srinivas on 2017-12-27 13:12)

Dear Helmut,
Much pleasure with your reply.

» study planned for 90% power: The chance to obtain a post hoc power of ≥95% is ~35%.

Is it a thumb rule? how it should be calculated?

» It only means that
»    – the CV was lower and/or
»    – the GMR closer to 1 and/or
»    – you had less dropouts than assumed.

Yes, on getting posthoc analysis, i found three aspects what you said:
After experiment, it came to know that
1. CV getting lower
2. GMR close to 1
3. No dropouts/withdrawls (though prior consideration of 10% dropouts)

Complete thread:

Activity
 Mix view
Bioequivalence and Bioavailability Forum |  Admin contact
18,883 posts in 4,027 threads, 1,271 registered users;
online 27 (0 registered, 27 guests [including 25 identified bots]).

Those who make no mistakes are making the biggest mistakes of all –
they are attempting nothing new.    Anthony de Mello

The BIOEQUIVALENCE / BIOAVAILABILITY FORUM is hosted by
BEBAC Ing. Helmut Schütz
HTML5 RSS Feed