Bioequivalence and Bioavailability Forum • AUC0-tau at steady state

AUC0-tau at steady state [NCA / SHAM]

posted by BNR – US, 2016-04-01 00:46 (3741 d 13:37 ago) – Posting: # 16159
Views: 26,498

I have a question about AUC0-tau calculation when using actual sampling time. For example, the dosing interval is 24 hr and the 24-hr sample was drawn at 23.8hr. If lambda is not able to be obtained (eg. the concentration-time profile is flat during dosing interval), Phoenix 6.4 will not calculate the AUC0-tau value as extrapolation is not possible. What is the best way to hand this case, reporting a missing value for AUC0-tau or replacing 23.8hr with 24hr for the calculation? Thanks for your help in advance!

Complete thread:

AUC0-tau at steady stateBNR 2016-03-31 22:46 [NCA / SHAM]
- AUC0-tau at steady state jag009 2016-03-31 23:05
  - AUC0-tau at steady state BNR 2016-03-31 23:43
    - RTFM Helmut 2016-04-01 00:59
      - RTFM BNR 2016-04-01 02:05
      - AUC0-τ estimation with time deviations Astea 2019-02-10 16:38
        
        AUC0-τ estimation with time deviations Helmut 2019-02-10 19:32
        
        Cτ for lin and lin-up/log-down Astea 2019-02-10 20:50
        
        Cτ by lin-/lin, lin-up/log-down, and λz Helmut 2019-02-11 01:45
        
        inter- vs extra- Astea 2019-02-11 19:46
        
        inter- vs extra- Helmut 2019-02-12 02:20
        No rule fits all mittyri 2019-02-14 12:55
        
        one size fits all vs goal posts Astea 2019-02-16 08:33
        
        one size fits all vs goal posts ElMaestro 2019-02-16 13:33
        
        Bias etc. Helmut 2019-02-16 14:26
        
        software: NCA not validated Helmut 2019-02-16 13:59
        
        no way out for NCA validation? mittyri 2019-02-20 21:22
        
        Default rules mittyri 2019-02-20 21:40