AUC0-tau at steady state [NCA / SHAM]

posted by BNR – US, 2016-03-31 23:43  – Posting: # 16161
Views: 5,643

(edited by BNR on 2016-04-01 00:52)

Hi John,

Thank you for your reply. I thought AUC0-tau not reported by Phoenix is because Lambda can't be calculated. I tested a simulated dataset for which the Lambda can be calculated. In this case, AUC0-tau is reported by Phoenix even though the actual sampling time 23.8 is used.
Please see two example datasets below. AUC0-tau (tau=24 hr) is not reported by Phoenix for the dataset 1. But it is reported for the dataset 2. For dataset 1, AUC0-tau will be reported by Phoenix if using the nominal time 24 hr. Would you recommend to use the actual sampling time of 23.8 hr with a missing AUCo-tau value or use the nominal time of 24 hr (which is not much different from the actual time in this case) and have a calculable AUC0-tau?


Data set 1   Data set 2
Time  Conc   Time  Conc
 0    1000    0    1000
 4    1500    4    1500
 8     900    8    1750
12    1750   12    1750
16    1000   16    1000
23.8   800   23.8   800

Edit: Data BBcoded & full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post! [Helmut]

Complete thread:

 Mix view
Bioequivalence and Bioavailability Forum |  Admin contact
19,478 posts in 4,133 threads, 1,333 registered users;
online 7 (0 registered, 7 guests [including 6 identified bots]).
Forum time (Europe/Vienna): 05:07 CEST

If you don’t know anything about computers,
just remember that they are machines that do exactly what you tell them
but often surprise you in the result.    Richard Dawkins

BEBAC Ing. Helmut Schütz