Bioequivalence and Bioavailability Forum • Sample size?

Sample size? [Power / Sample Size]

posted by Helmut – Vienna, Austria, 2012-11-20 21:10 (4613 d 11:39 ago) – Posting: # 9563
Views: 15,800

Hi Torn!

Adding to what ElMaestro said my two cents: Maybe you can point out (in a polite way I’m not an expert in) that if one increases the sample size sooner or later any study will show a significant difference if the ratio is not exactly (!) 1. See this post. I don’t know your CV and sample size, but the sponsor cannot be blamed to have performed a study in “too” many subjects (I would avoid the term overpowered).

Horatio: He waxes desperate with imagination.
Marcellus: Let’s follow. ’Tis not fit thus to obey him.
Horatio: Have after. To what issue will this come?
Marcellus: Something is rotten in the state of Denmark.
Horatio: Heaven will direct it.
Marcellus: Nay, let’s follow him.

—
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Helmut Schütz

The quality of responses received is directly proportional to the quality of the question asked. 🚮
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Complete thread:

Significance The Outlaw Torn 2012-11-20 07:56 [Power / Sample Size]
- Significance ElMaestro 2012-11-20 08:17
  - Significance The Outlaw Torn 2012-11-20 08:55
    - Quality vs. Clinical ElMaestro 2012-11-20 09:04
- Sample size?Helmut 2012-11-20 20:10
  - Sample size? The Outlaw Torn 2012-11-21 07:52
  - Sample size? The Outlaw Torn 2012-11-22 10:55
    - Sample size, ratio, CV ↔ power Helmut 2012-11-22 13:35
      - Sample size, ratio, CV ↔ power The Outlaw Torn 2012-11-23 14:47
      - Sample size, ratio, CV ↔ power BEQool 2025-01-31 13:12
        
        TOST != treatment effect mittyri 2025-02-20 13:13
        Sample size, ratio, CV ↔ power zizou 2025-02-21 13:40
        
        Not vice versa mittyri 2025-02-22 21:08
        
        Not vice versa? zizou 2025-02-24 11:02
        
        Not vice versa? mittyri 2025-02-25 06:12
- Sample size calculation using Marzo and Balant method kumarnaidu 2013-01-31 07:48
  - Marzo / Balant formula d_labes 2013-01-31 10:05
    - Marzo / Balant formula kumarnaidu 2013-01-31 10:54
      - Marzo / Balant formula kumarnaidu 2013-02-04 05:48
        
        Marzo / Balant formula for parallel groups d_labes 2013-02-04 08:44