Bioequivalence and Bioavailability Forum • total (pooled) variance: examples

total (pooled) variance: examples [Power / Sample Size]

posted by BEQool – Slovenia, 2023-05-04 10:17 (32 d 05:47 ago) – Posting: # 23542
Views: 186

❝ Btw. total (pooled) CV in 2x2x2 can also be obtained by fitting the model with factors Formulations, Periods, Sequences (i.e. without Subjects(Sequences)). Then use MSE in equation:

❝ CV=sqrt(e^(MSE)-1) (multiplicative model with residual variance sigma^2 which is estimated by MSE from ANOVA)

❝ For parallel design, it's trivial and only the total (pooled) CV can be obtained.

Interesting, thanks!

❝ For higher-order designs with more than two formulations I never tried it but it could be another option for recalculation.

Just for curiosity, with above mentioned data I tried some calculations for 3x6x3 design with and without factor Subject(Sequence) for both approaches (All at once and Two at a time) but I couldnt get matched CVtotal numbers so like you said there is probably another option for recalculation.

❝ ❝ ... it could happen with real-world data as well?

❝ Sometimes (not often) it happens. It was discussed e.g. in this thread.

Thanks!

Complete thread:

Sample size estimation for parallel design Nav Coelho 2007-07-20 16:14 [Power / Sample Size]
- Parallel designs (total variance) Helmut 2007-07-20 16:29
  - Parallel designs (total variance) Nav Coelho 2007-07-20 18:38
    - CV-intra # 60% CV-inter Helmut 2007-07-22 01:17
    - total (pooled) variance: examples Helmut 2007-07-23 17:44
      - total (pooled) variance: examples Nav Coelho 2007-07-23 19:58
      - total (pooled) variance: examples BEQool 2023-04-18 09:59
        
        Higher-Order Crossovers Helmut 2023-04-20 10:19
        
        Higher-Order Crossovers BEQool 2023-04-21 07:53
        
        total (pooled) variance: examples zizou 2023-04-21 21:23
        
        total (pooled) variance: examples BEQool 2023-04-22 18:20
        
        total (pooled) variance: examples zizou 2023-04-22 21:06
        
        total (pooled) variance: examples BEQool 2023-04-25 10:57
        
        total (pooled) variance: examples zizou 2023-04-25 22:43
        
        total (pooled) variance: examplesBEQool 2023-05-04 08:17
- Sample size estimation for parallel design Dipesh Jayswal 2007-07-24 08:52