How to calculate intersubject variability in PHX WinNonlin [Software]

posted by zan – US, 2014-01-30 00:58 (3601 d 05:02 ago) – Posting: # 12289
Views: 27,179

I encountered a negative Var(residual) for Cmax in PHX winnonlin when I run the 2x2 crossover test for intersubject and intrasubject CV% for Cmax and AUC.
I was able to obtain the intrasub CV for both parameters but the intersub CV for Cmax is missing. However I would still like to get the estimate for this intersub CV, I was wondering how can I calculate this value out in this case.

My limited searching tells me that this might be due to intersub CV% < intrasub CV%. What is the caution and steps to do when seeing this phenomena in the results?

Many thanks


Edit: Category changed. [Helmut]

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