Assumptions… [Power / Sample Size]

posted by Helmut Homepage – Vienna, Austria, 2019-09-09 14:09 (537 d 07:07 ago) – Posting: # 20558
Views: 3,868

Hi Rocco,

see what I wrote above.
Since you have no idea about the new formulation you have to assume indeed that the variances of T and R are at least similar. If you don’t like this assumption, there are just two ways out:
  1. Pilot study or
  2. Adaptive Two-Stage Sequential design.
Even if you are wary and walk this road, you have to assume things. The CV and the T/R-ratio are estimates and therefore, uncertain. Relying on assumptions is part of the game. Only death is certain.

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