## Assumptions… [Power / Sample Size]

Hi Rocco,

see what I wrote above.

Since you have no idea about the new formulation you have to

see what I wrote above.

Since you have no idea about the new formulation you have to

*assume*indeed that the variances of T and R are at least similar. If you don’t like this assumption, there are just two ways out:- Pilot study or

- Adaptive Two-Stage Sequential design.

*assume*things. The CV and the T/R-ratio are*estimates*and therefore, uncertain. Relying on assumptions is part of the game. Only death is certain.—

Cheers,

Helmut Schütz

The quality of responses received is directly proportional to the quality of the question asked. ☼

Science Quotes

Cheers,

Helmut Schütz

The quality of responses received is directly proportional to the quality of the question asked. ☼

Science Quotes

### Complete thread:

- Input for CV when small first-in-man has been run Rocco_M 2019-09-03 18:45 [Power / Sample Size]
- Geometric mean and CV Helmut 2019-09-05 14:05
- Geometric mean and CV Rocco_M 2019-09-05 23:49
- Geometric mean and CV Helmut 2019-09-06 00:15
- Geometric mean and CV Rocco_M 2019-09-06 17:49
- Geometric mean and CV Helmut 2019-09-06 18:15
- Geometric mean and CV ElMaestro 2019-09-06 19:03
- Geometric mean and CV Helmut 2019-09-07 09:57
- Geometric mean and CV Rocco_M 2019-09-09 13:31
- Assumptions… Helmut 2019-09-09 14:09
- Assumptions… Rocco_M 2019-09-09 16:35
- Assumptions… Helmut 2019-09-09 17:19
- Assumptions… Rocco_M 2019-09-13 21:28
- t-test & Welch-test Helmut 2019-09-14 00:16
- sampleN.TOST and CI.BE Rocco_M 2019-09-17 22:02
- assumptions vs. realizations Helmut 2019-09-18 11:04

- sampleN.TOST and CI.BE Rocco_M 2019-09-17 22:02

- t-test & Welch-test Helmut 2019-09-14 00:16

- Assumptions… Rocco_M 2019-09-13 21:28

- Assumptions… Helmut 2019-09-09 17:19

- Assumptions… Rocco_M 2019-09-09 16:35

- Assumptions… Helmut 2019-09-09 14:09

- Geometric mean and CV Rocco_M 2019-09-09 13:31

- Geometric mean and CV Helmut 2019-09-07 09:57

- Geometric mean and CV ElMaestro 2019-09-06 19:03

- Geometric mean and CV Helmut 2019-09-06 18:15

- Geometric mean and CV Rocco_M 2019-09-06 17:49

- Geometric mean and CV Helmut 2019-09-06 00:15

- Geometric mean and CV Rocco_M 2019-09-05 23:49

- Geometric mean and CV Helmut 2019-09-05 14:05