## Geometric mean and CV [Power / Sample Size]

Hi Rocco,

» So basically your analysis follows from the fact that the variance of the difference of T and R equal the sum of the variance of T and the variance of R, correct?

Well, you have four variance components (s²

» And you are using the geometric CV as the estimate of CVp for R?

Yes.

» So basically your analysis follows from the fact that the variance of the difference of T and R equal the sum of the variance of T and the variance of R, correct?

Well, you have four variance components (s²

_{wR}, s²_{wT}, s²_{bT}, s²_{bR}). Then- Full replicate designs

All are identifiable.

- 2×2×2 crossover (balanced and complete for simplicity – otherwise, weighting is required)

s²w = (s²_{wR}+ s²_{wT})/2 and s²_{b}= (s²_{bT}+ s²_{bR})/2.

- 2 group parallel

Only the pooled (total) s²_{p}. With a tricky mixed-effects model you could get s²_{pT}and s²_{pR}.

- One treatment (FIM)

Only s²_{p}.

*similar*.» And you are using the geometric CV as the estimate of CVp for R?

Yes.

—

Helmut Schütz

The quality of responses received is directly proportional to the quality of the question asked. 🚮

Science Quotes

*Dif-tor heh smusma*🖖Helmut Schütz

The quality of responses received is directly proportional to the quality of the question asked. 🚮

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### Complete thread:

- Input for CV when small first-in-man has been run Rocco_M 2019-09-03 18:45 [Power / Sample Size]
- Geometric mean and CV Helmut 2019-09-05 14:05
- Geometric mean and CV Rocco_M 2019-09-05 23:49
- Geometric mean and CV Helmut 2019-09-06 00:15
- Geometric mean and CV Rocco_M 2019-09-06 17:49
- Geometric mean and CVHelmut 2019-09-06 18:15
- Geometric mean and CV ElMaestro 2019-09-06 19:03
- Geometric mean and CV Helmut 2019-09-07 09:57
- Geometric mean and CV Rocco_M 2019-09-09 13:31
- Assumptions… Helmut 2019-09-09 14:09
- Assumptions… Rocco_M 2019-09-09 16:35
- Assumptions… Helmut 2019-09-09 17:19
- Assumptions… Rocco_M 2019-09-13 21:28
- t-test & Welch-test Helmut 2019-09-14 00:16
- sampleN.TOST and CI.BE Rocco_M 2019-09-17 22:02
- assumptions vs. realizations Helmut 2019-09-18 11:04

- sampleN.TOST and CI.BE Rocco_M 2019-09-17 22:02

- t-test & Welch-test Helmut 2019-09-14 00:16

- Assumptions… Rocco_M 2019-09-13 21:28

- Assumptions… Helmut 2019-09-09 17:19

- Assumptions… Rocco_M 2019-09-09 16:35

- Assumptions… Helmut 2019-09-09 14:09

- Geometric mean and CV Rocco_M 2019-09-09 13:31

- Geometric mean and CV Helmut 2019-09-07 09:57

- Geometric mean and CV ElMaestro 2019-09-06 19:03

- Geometric mean and CVHelmut 2019-09-06 18:15

- Geometric mean and CV Rocco_M 2019-09-06 17:49

- Geometric mean and CV Helmut 2019-09-06 00:15

- Geometric mean and CV Rocco_M 2019-09-05 23:49

- Geometric mean and CV Helmut 2019-09-05 14:05