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RegisterAUC0-tau at steady state [NCA / SHAM]
Hi John,
Thank you for your reply. I thought AUC0-tau not reported by Phoenix is because Lambda can't be calculated. I tested a simulated dataset for which the Lambda can be calculated. In this case, AUC0-tau is reported by Phoenix even though the actual sampling time 23.8 is used.
Please see two example datasets below. AUC0-tau (tau=24 hr) is not reported by Phoenix for the dataset 1. But it is reported for the dataset 2. For dataset 1, AUC0-tau will be reported by Phoenix if using the nominal time 24 hr. Would you recommend to use the actual sampling time of 23.8 hr with a missing AUCo-tau value or use the nominal time of 24 hr (which is not much different from the actual time in this case) and have a calculable AUC0-tau?
Thanks.
Edit: Data BBcoded & full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post! [Helmut]
Thank you for your reply. I thought AUC0-tau not reported by Phoenix is because Lambda can't be calculated. I tested a simulated dataset for which the Lambda can be calculated. In this case, AUC0-tau is reported by Phoenix even though the actual sampling time 23.8 is used.
Please see two example datasets below. AUC0-tau (tau=24 hr) is not reported by Phoenix for the dataset 1. But it is reported for the dataset 2. For dataset 1, AUC0-tau will be reported by Phoenix if using the nominal time 24 hr. Would you recommend to use the actual sampling time of 23.8 hr with a missing AUCo-tau value or use the nominal time of 24 hr (which is not much different from the actual time in this case) and have a calculable AUC0-tau?
Thanks.
Data set 1 Data set 2
Time Conc Time Conc
0 1000 0 1000
4 1500 4 1500
8 900 8 1750
12 1750 12 1750
16 1000 16 1000
23.8 800 23.8 800Edit: Data BBcoded & full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post! [Helmut]
Complete thread:
- AUC0-tau at steady state BNR 2016-03-31 22:46 [NCA / SHAM]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- AUC0-tau at steady state jag009 2016-03-31 23:05
- AUC0-tau at steady stateBNR 2016-03-31 23:43
- RTFM Helmut 2016-04-01 00:59
- RTFM BNR 2016-04-01 02:05
- AUC0-τ estimation with time deviations Astea 2019-02-10 16:38
- AUC0-τ estimation with time deviations Helmut 2019-02-10 19:32
- Cτ for lin and lin-up/log-down Astea 2019-02-10 20:50
- Cτ by lin-/lin, lin-up/log-down, and λz Helmut 2019-02-11 01:45
- inter- vs extra- Astea 2019-02-11 19:46
- inter- vs extra- Helmut 2019-02-12 02:20
- No rule fits all mittyri 2019-02-14 12:55
- one size fits all vs goal posts Astea 2019-02-16 08:33
- one size fits all vs goal posts ElMaestro 2019-02-16 13:33
- Bias etc. Helmut 2019-02-16 14:26
- software: NCA not validated Helmut 2019-02-16 13:59
- no way out for NCA validation? mittyri 2019-02-20 21:22
- Default rules mittyri 2019-02-20 21:40
- one size fits all vs goal posts ElMaestro 2019-02-16 13:33
- one size fits all vs goal posts Astea 2019-02-16 08:33
- inter- vs extra- Astea 2019-02-11 19:46
- Cτ by lin-/lin, lin-up/log-down, and λz Helmut 2019-02-11 01:45
- Cτ for lin and lin-up/log-down Astea 2019-02-10 20:50
- AUC0-τ estimation with time deviations Helmut 2019-02-10 19:32
- RTFM Helmut 2016-04-01 00:59
- AUC0-tau at steady stateBNR 2016-03-31 23:43
- AUC0-tau at steady state jag009 2016-03-31 23:05
Ing. Helmut Schütz