Bigamist [Power / Sample Size]
Dear Helmut!
They would call me "Bigamist" and send me to prison in many countries. And I think my spouse wouldn't be very amused if I convert to a Mussulmán in my old days
.
But anyhow: Thanks for the flowers.
I'm not quite sure if you are right here. In simulating 2-stage adaptive designs the power/sample size steps may contribute considerably to the computation times. Thus they may stay the show-stopper even if we can push on the calculations of stage 1/stage 2 BE by the ideas behind power.scABEL() or behind the code inthis post.
But lets see ...
2-stage design combined with RSABE will have another drawback: Where is the point for simulations which represents alpha
? Simply GMR=1.25 (or whatever BE limit applies) surely not.
Eventually power.scABEL() will help to explore.
❝ Do you want to marry me? The community will love you for that!
They would call me "Bigamist" and send me to prison in many countries. And I think my spouse wouldn't be very amused if I convert to a Mussulmán in my old days

But anyhow: Thanks for the flowers.
❝ Opens even the door for two-stage simulations where the intermediate power/sample size was the actual show-stopper.
I'm not quite sure if you are right here. In simulating 2-stage adaptive designs the power/sample size steps may contribute considerably to the computation times. Thus they may stay the show-stopper even if we can push on the calculations of stage 1/stage 2 BE by the ideas behind power.scABEL() or behind the code inthis post.
But lets see ...
2-stage design combined with RSABE will have another drawback: Where is the point for simulations which represents alpha

Eventually power.scABEL() will help to explore.
—
Regards,
Detlew
Regards,
Detlew
Complete thread:
- Sample size for RSABE Anu 2013-02-01 07:01 [Power / Sample Size]
- Sample size for RSABE d_labes 2013-02-01 09:46
- Sample size for RSABE Anu 2013-02-07 06:58
- No analytic solution! Helmut 2013-02-07 12:32
- Coming soon ... d_labes 2013-02-08 11:57
- Wow! Helmut 2013-02-08 12:19
- Wow! Anu 2013-02-09 09:20
- read… Helmut 2013-02-09 09:35
- Bigamistd_labes 2013-02-09 18:11
- Some testing (Part I) Helmut 2013-02-10 18:35
- Some testing (Part II) Helmut 2013-02-11 01:00
- Power testing d_labes 2013-02-11 12:03
- the unknown x Helmut 2013-02-11 14:40
- Unequal CVs d_labes 2013-02-15 08:47
- Typo Helmut 2013-02-15 13:01
- Power testing d_labes 2013-02-11 12:03
- Wow! Anu 2013-02-09 09:20
- Wow! Helmut 2013-02-08 12:19
- Coming soon ... d_labes 2013-02-08 11:57
- No analytic solution! Helmut 2013-02-07 12:32
- Sample size for RSABE Anu 2013-02-07 06:58
- Sample size for RSABE d_labes 2013-02-01 09:46