Bioequivalence and Bioavailability Forum • Variances from ABE: different model

Variances from ABE: different model [RSABE / ABEL]

posted by jag009 – NJ, 2013-01-15 19:17 (4502 d 15:19 ago) – Posting: # 9853
Views: 14,890
(edited on 2013-01-15 20:00)

Hi Helmut,

❝ Correct; n-m, where m=2 in the fully replicated. Therefore, my F-values are 2.333484 and 0.4285438 (from R, since not accessible in PHX).

Yes I got those results as well in SAS. How do you come up with the CL value? I need food, hungry, can't think (damn lunch time here)...

According to the equation in the warfarin guidance
(1-alpha)100%CI = (SWT/SWR)/Sqrt(F₁), (SWT/SWR)/Sqrt(F₂), where
F₁=F_{alpha/2,v1,v2}, F₂=F_{1-alpha/2,v1,v2}

I ended up getting 0.13134956, 0.306502082???

I am not smoking weed at this moment, its illegal anyway...

John

Complete thread:

FDA’s aggregate BE for NTIDs: example Helmut 2013-01-13 15:54 [RSABE / ABEL]
- 404 d_labes 2013-01-13 19:06
  - URL corrected Helmut 2013-01-13 20:49
    - URL corrected jag009 2013-01-14 21:09
      - THX! Helmut 2013-01-14 21:50
        
        THX! jag009 2013-01-14 21:53
        
        Home stretch Helmut 2013-01-14 22:07
        
        Home stretch jag009 2013-01-14 22:24
        
        estimate K2K 2013-01-16 04:48
        
        only a typo in John’s code Helmut 2013-01-16 14:00
        
        only a typo in John’s code K2K 2013-01-17 04:46
- FDA’s aggregate BE for NTIDs: example jag009 2013-01-14 23:04
  - Variances from ABE: different model Helmut 2013-01-15 15:41
    - Variances from ABE: different model jag009 2013-01-15 17:58
      - Variances from ABE: different model Helmut 2013-01-15 18:09
        
        Variances from ABE: different modeljag009 2013-01-15 18:17
        
        Yep. Almost there. Helmut 2013-01-15 23:30
        
        Yep. Almost there. jag009 2013-01-16 16:14
        
        Done Helmut 2013-01-20 12:58
        
        Variances from ABE: different model jag009 2013-01-15 18:19
        
        Variances from ABE: different model Helmut 2013-01-15 18:29
        
        Variances from ABE: different model jag009 2013-01-15 19:49
        Variances from ABE: different model jag009 2013-01-16 19:35
        
        Variances from ABE: different model Helmut 2013-01-16 19:39