Bioequivalence and Bioavailability Forum

‘alpha’ of scaled ABE? d_labes 2013-03-15 15:56
- ‘alpha’ of scaled ABE? Helmut 2013-03-15 17:27
  - ’alpha’ of scaled ABE: design d_labes 2013-03-16 20:10
    - N=24, 48 d_labes 2013-03-18 08:11
      - adaptive design without adjustment martin 2013-03-25 20:47
        
        α adjustment? Helmut 2013-03-26 15:21
        
        iteratively adjusted alpha martin 2013-03-26 16:19
        
        throw away our sample size tables? Helmut 2013-03-26 18:02
        
        if real martin 2013-03-26 19:44
        
        regulators don’t care? Helmut 2013-03-26 21:18
        
        adjusting α Helmut 2013-08-11 16:19
        
        missing letter apapanas 2024-10-31 06:02
        
        PowerTOST: sampleN.scABEL.ad() Helmut 2024-10-31 08:41
        
        PowerTOST: sampleN.scABEL.ad() apapanas 2024-11-08 10:48
        
        Molins et al. (2017) Helmut 2024-11-08 14:34
        
        target α in sim’s? Helmut 2013-03-27 15:38
        
        target α in sim’s? martin 2013-03-27 16:36
        
        If it is real: results Helmut 2013-03-28 23:20
        
        having alpha martin 2013-03-28 15:08
        
        fixed swr Helmut 2013-03-28 23:34
        
        fixed swr martin 2013-03-29 15:07
        
        Yes but no but yes but no but… Helmut 2013-03-29 16:10

data management Imph 2024-03-14 09:57
- data management BEQool 2024-03-14 15:47

homoscedasticity assumption in RSABE method WinnieH 2023-08-18 08:57
- heteroscedasticity in RSABE (and ABEL) Helmut 2023-08-18 11:23
  - heteroscedasticity in RSABE (and ABEL) WinnieH 2023-08-18 13:05
- homoscedasticity assumption in RSABE method BEQool 2023-08-18 12:30
  - Asking a pupil d_labes 2023-08-18 14:11
    - Asking a pupil BEQool 2023-08-18 17:16

any SAS or R-macro for 3 period two sequence RSABEIs Achievwin 2023-07-05 18:38
- Use the one for TRTR | RTRT Helmut 2023-07-06 08:46
  - RSABE R coded by Detlew mittyri 2023-07-06 14:07
    - ‘dlat’ for 3-period full replicate? Helmut 2023-07-07 14:41
      - ‘dlat’ for 3-period full replicate? mittyri 2023-07-07 16:04
        
        Likely wrong workaround? Helmut 2023-07-07 20:06
        
        a bit corrected workaround mittyri 2023-07-07 22:52
        
        THX! Another attempt… Helmut 2023-07-08 12:15
        
        complete.cases for dlat and ilat? mittyri 2023-07-09 21:45
        
        a bit corrected workaround Achievwin 2023-07-10 20:43

Reference-Scaled Average Bioequivalence Brus 2023-06-06 12:18
- FDA: TRT|RTR instead of TRR|RTR|RRT? Helmut 2023-06-07 10:22

Upper confidence bound and confidence interval of RSABE WinnieH 2023-03-21 10:58

Questions on understanding the 4-way RSABE method SAS code WinnieH 2023-01-04 13:33
- Questions on understanding the 4-way RSABE method SAS code Helmut 2023-01-04 14:02
  - Questions on understanding the 4-way RSABE method SAS code WinnieH 2023-01-04 15:12

scale average bioequivalence for parallel design Mahmoud 2022-06-15 12:33
- Parallel design: Maybe (‼) in exceptional cases Helmut 2022-06-15 14:08
  - Parallel design: Maybe (‼) in exceptional cases Mahmoud 2022-06-15 23:26

Sample size and power Helmut 2022-03-28 13:39

Sample Size Efficiency of 4-Period, 2-Seq, 2-Formulation Design Sereng 2022-01-28 19:37
- Sample Size Efficiency of 4-Period, 2-Seq, 2-Formulation Design Helmut 2022-01-28 21:06
  - Sample Size Efficiency of 4-Period, 2-Seq, 2-Formulation Design Sereng 2022-01-28 21:40
    - NTIDs Helmut 2022-01-29 12:19

FDA: SAS-code for NTIDs Bebac user 2021-12-06 00:36
- FDA: SAS-code for NTIDs Helmut 2021-12-06 10:55

Inter-subject variability in Full replicate design MGR 2021-09-30 07:35
- Inter-subject variability in Full replicate design ElMaestro 2021-09-30 14:04
- Inter-subject variability in Full replicate design Helmut 2021-09-30 15:25

If we have any methods to widen CI in parallel design with high variance drug? libaiyi 2021-02-02 09:39
- If we have any methods to widen CI in parallel design with high variance drug? ElMaestro 2021-02-02 11:12
  - If we have any methods to widen CI in parallel design with high variance drug? libaiyi 2021-02-02 11:40

95% upper bound limit as per FDA for fully replicate crossover BE study yogeshla 2021-01-05 07:01
- 95% upper bound limit as per FDA for fully replicate crossover BE study dshah 2021-01-05 08:06
  - 0.001 > 0 Helmut 2021-01-05 11:01
    - 0.001 > 0 yogeshla 2021-01-05 12:33

Inflated type I error with fixed widened limits? Helmut 2020-11-25 10:50
- Inflated type I error with fixed widened limits? d_labes 2020-11-25 15:07
  - Inflated type I error with fixed widened limits? Helmut 2020-11-26 00:09
    - Inflated type I error with fixed widened limits d_labes 2020-11-26 15:38
      - Inflated type I error: Not nice Helmut 2020-11-26 17:14
        
        Power of the GCC framework and power of PowerTOST d_labes 2020-11-28 11:20
        
        Sample sizes (ignoring the inflated TIE) Helmut 2020-11-29 11:21
        
        Bug? d_labes 2020-11-29 16:22
        
        “Feature” Helmut 2020-11-30 00:16
- Inflated type I error with fixed widened limits? wienui 2020-11-29 14:03
  - Inflated type I error with fixed widened limits d_labes 2020-11-29 17:51
    - Inflated type I error with fixed widened limits Helmut 2020-11-30 00:14
      - Inflated type I error with fixed widened limits wienui 2020-11-30 03:30
        
        Houston, we have a problem! Helmut 2020-11-30 14:42
        
        Paradox of tolerance Astea 2020-12-01 23:34
        
        Οὐτοπεία ∨ Εὐτοπεία Helmut 2020-12-02 01:37
        
        Uchronia Astea 2020-12-02 09:46
        
        Steampunk Helmut 2020-12-02 11:34
        
        Dieselpunk Astea 2020-12-02 15:28
        
        Dieselpunk Helmut 2020-12-02 16:18
        
        Steampunk? OT d_labes 2020-12-02 19:30
        
        Steampunk? OT Astea 2020-12-02 19:58
        
        PowerTOST 1.5-2.9000 on GitHub Helmut 2020-12-23 12:18