Bioequivalence and Bioavailability Forum

Simulation of inter-subject variability in replicate study Shuanghe 2025-12-14 17:35
- Simulation of inter-subject variability in replicate study mittyri 2025-12-18 14:07
  - Simulation of inter-subject variability in replicate study Shuanghe 2025-12-30 10:22
    - ABE for partial replicate design acc. to the FDA Helmut 2025-12-30 11:11
      - ABE for partial replicate design acc. to the FDA Nirali 2026-02-18 12:04

Partial replicate design Silva 2013-12-31 12:17
- extra-reference design Helmut 2013-12-31 14:28
  - extra-reference design BEQool 2025-12-22 18:27
    - extra-reference design: R code mittyri 2025-12-23 11:58
      - extra-reference design: R code BEQool 2025-12-29 14:17
        
        extra-reference design: no period effect assumption mittyri 2025-12-29 22:16
        
        extra-reference design: no period effect assumption BEQool 2025-12-31 16:42

‘alpha’ of scaled ABE? d_labes 2013-03-15 15:56
- ‘alpha’ of scaled ABE? Helmut 2013-03-15 17:27
  - ’alpha’ of scaled ABE: design d_labes 2013-03-16 20:10
    - N=24, 48 d_labes 2013-03-18 08:11
      - adaptive design without adjustment martin 2013-03-25 20:47
        
        α adjustment? Helmut 2013-03-26 15:21
        
        iteratively adjusted alpha martin 2013-03-26 16:19
        
        throw away our sample size tables? Helmut 2013-03-26 18:02
        
        if real martin 2013-03-26 19:44
        
        regulators don’t care? Helmut 2013-03-26 21:18
        
        adjusting α Helmut 2013-08-11 16:19
        
        missing letter apapanas 2024-10-31 06:02
        
        PowerTOST: sampleN.scABEL.ad() Helmut 2024-10-31 08:41
        
        PowerTOST: sampleN.scABEL.ad() apapanas 2024-11-08 10:48
        
        Molins et al. (2017) Helmut 2024-11-08 14:34
        
        target α in sim’s? Helmut 2013-03-27 15:38
        
        target α in sim’s? martin 2013-03-27 16:36
        
        If it is real: results Helmut 2013-03-28 23:20
        
        having alpha martin 2013-03-28 15:08
        
        fixed swr Helmut 2013-03-28 23:34
        
        fixed swr martin 2013-03-29 15:07
        
        Yes but no but yes but no but… Helmut 2013-03-29 16:10

data management Imph 2024-03-14 09:57
- data management BEQool 2024-03-14 15:47

homoscedasticity assumption in RSABE method WinnieH 2023-08-18 08:57
- heteroscedasticity in RSABE (and ABEL) Helmut 2023-08-18 11:23
  - heteroscedasticity in RSABE (and ABEL) WinnieH 2023-08-18 13:05
- homoscedasticity assumption in RSABE method BEQool 2023-08-18 12:30
  - Asking a pupil d_labes 2023-08-18 14:11
    - Asking a pupil BEQool 2023-08-18 17:16

any SAS or R-macro for 3 period two sequence RSABEIs Achievwin 2023-07-05 18:38
- Use the one for TRTR | RTRT Helmut 2023-07-06 08:46
  - RSABE R coded by Detlew mittyri 2023-07-06 14:07
    - ‘dlat’ for 3-period full replicate? Helmut 2023-07-07 14:41
      - ‘dlat’ for 3-period full replicate? mittyri 2023-07-07 16:04
        
        Likely wrong workaround? Helmut 2023-07-07 20:06
        
        a bit corrected workaround mittyri 2023-07-07 22:52
        
        THX! Another attempt… Helmut 2023-07-08 12:15
        
        complete.cases for dlat and ilat? mittyri 2023-07-09 21:45
        
        a bit corrected workaround Achievwin 2023-07-10 20:43

Reference-Scaled Average Bioequivalence Brus 2023-06-06 12:18
- FDA: TRT|RTR instead of TRR|RTR|RRT? Helmut 2023-06-07 10:22

Upper confidence bound and confidence interval of RSABE WinnieH 2023-03-21 10:58

Questions on understanding the 4-way RSABE method SAS code WinnieH 2023-01-04 13:33
- Questions on understanding the 4-way RSABE method SAS code Helmut 2023-01-04 14:02
  - Questions on understanding the 4-way RSABE method SAS code WinnieH 2023-01-04 15:12

scale average bioequivalence for parallel design Mahmoud 2022-06-15 12:33
- Parallel design: Maybe (‼) in exceptional cases Helmut 2022-06-15 14:08
  - Parallel design: Maybe (‼) in exceptional cases Mahmoud 2022-06-15 23:26

Sample size and power Helmut 2022-03-28 13:39

Sample Size Efficiency of 4-Period, 2-Seq, 2-Formulation Design Sereng 2022-01-28 19:37
- Sample Size Efficiency of 4-Period, 2-Seq, 2-Formulation Design Helmut 2022-01-28 21:06
  - Sample Size Efficiency of 4-Period, 2-Seq, 2-Formulation Design Sereng 2022-01-28 21:40
    - NTIDs Helmut 2022-01-29 12:19

FDA: SAS-code for NTIDs Bebac user 2021-12-06 00:36
- FDA: SAS-code for NTIDs Helmut 2021-12-06 10:55

Inter-subject variability in Full replicate design MGR 2021-09-30 07:35
- Inter-subject variability in Full replicate design ElMaestro 2021-09-30 14:04
- Inter-subject variability in Full replicate design Helmut 2021-09-30 15:25

If we have any methods to widen CI in parallel design with high variance drug? libaiyi 2021-02-02 09:39
- If we have any methods to widen CI in parallel design with high variance drug? ElMaestro 2021-02-02 11:12
  - If we have any methods to widen CI in parallel design with high variance drug? libaiyi 2021-02-02 11:40

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