PAR not yet [Two-Stage / GS Designs]

posted by The Outlaw Torn – Europe, 2011-10-27 11:07 (3486 d 10:19 ago) – Posting: # 7551
Views: 12,934

Hello all,

We provided our protocol to a central European country and this is what they responded about Potvin method C:

“Method C” as proposed in this publication is not acceptable, as type I error is not controlled on the 5% level and alternative methods securing type I error control are available.

They go on to suggest method B because "The authors demonstrate by simulations that the power of this method is only slightly lower than for “Method C”, resulting in comparable mean total number of subjects."

Any comments?

Thanks.

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