- T1E after 1st stage in Power2Stage mittyri 2022-06-24 13:43
- T1E after 1st stage in TSDs Helmut 2022-06-24 14:33
- T1E after 1st stage in TSDs mittyri 2022-06-24 21:12
- T1E after 1st stage in TSDs Helmut 2022-06-25 14:07
- Potvin C consequences mittyri 2022-06-25 23:29
- Potvin C consequences ElMaestro 2022-06-26 09:11
- Potvin C consequences mittyri 2022-06-27 13:45
- Potvin C consequences Helmut 2022-06-27 14:49
- from Potvin C to Inverse Normal mittyri 2022-06-27 17:13
- From Potvin C to Inverse Normal: history (and outlook?) Helmut 2022-06-27 18:54
- from Potvin C to Inverse Normal mittyri 2022-06-27 17:13
- Potvin C consequences ElMaestro 2022-06-27 17:13
- true CV ≠ observed CV mittyri 2022-06-27 17:22
- Potvin C consequences Helmut 2022-06-27 14:49
- Potvin C consequences mittyri 2022-06-27 13:45
- Potvin C consequences ElMaestro 2022-06-26 09:11
- Potvin C consequences mittyri 2022-06-25 23:29
- T1E after 1st stage in TSDs Helmut 2022-06-25 14:07
- T1E after 1st stage in TSDs mittyri 2022-06-24 21:12
- T1E after 1st stage in Power2Stage ElMaestro 2022-06-24 18:25
- T1E after 1st stage in Power2Stage mittyri 2022-06-24 21:05
- T1E after 1st stage in Power2Stage ElMaestro 2022-06-24 22:55
- T1E after 1st stage in Power2Stage mittyri 2022-06-24 21:05
- T1E after 1st stage in TSDs Helmut 2022-06-24 14:33
- Two Stage Desing: ANOVA earlybird 2009-10-16 11:25
- Potvin et al: effects in stage 2 Helmut 2009-10-16 13:32
- Potvin et al: effects in stage 2 d_stat 2021-07-19 16:26
- Forget simulation-based TSDs for 2×2×2 in Europe Helmut 2021-07-19 17:22
- TSD statistical model - with multiple sites d_stat 2021-07-20 13:58
- TSD statistical model - with multiple sites Helmut 2021-07-20 21:52
- TSD statistical model - with multiple sites d_stat 2021-10-11 17:48
- TSD statistical model - with multiple sites Helmut 2021-10-12 11:27
- TSD statistical model - with multiple sites d_stat 2021-10-11 17:48
- TSD statistical model - with multiple sites Helmut 2021-07-20 21:52
- TSD statistical model - with multiple sites d_stat 2021-07-20 13:58
- Forget simulation-based TSDs for 2×2×2 in Europe Helmut 2021-07-19 17:22
- Potvin et al: effects in stage 2 d_stat 2021-07-19 16:26
- Potvin et al: effects in stage 2 Helmut 2009-10-16 13:32
- Two-stage design Regulatory Mikkabel 2020-06-23 17:42
- EMA: TSDs Helmut 2020-06-23 18:22
- ANVISA guidelines for two-stage design Mauricio Sampaio 2020-02-11 20:52
- Brainless copy-and-paste-devil Helmut 2020-02-12 02:26
- Brainless copy-and-paste-devil Mauricio Sampaio 2020-02-12 17:33
- ANVISA guidelines for two-stage design ElMaestro 2020-02-12 08:27
- ANVISA guidelines for two-stage design nobody 2020-02-12 08:49
- ANVISA guidelines for two-stage design Helmut 2020-02-12 13:12
- ANVISA guidelines for two-stage design Mauricio Sampaio 2020-02-12 17:04
- ANVISA guidelines for two-stage design Mauricio Sampaio 2020-02-12 17:11
- ANVISA guidelines for two-stage design ElMaestro 2020-02-12 21:54
- crap Helmut 2020-02-15 17:53
- crap Mauricio Sampaio 2020-02-16 05:01
- crap Helmut 2020-02-16 15:43
- crap d_labes 2020-02-16 19:34
- Explained crap remains crap Helmut 2020-02-17 12:49
- Proposed changes Mauricio Sampaio 2020-02-17 13:50
- Proposed changes Helmut 2020-02-17 14:16
- Proposed changes Mauricio Sampaio 2020-02-17 13:50
- Explained crap remains crap Helmut 2020-02-17 12:49
- crap d_labes 2020-02-16 19:34
- crap Helmut 2020-02-16 15:43
- crap Mauricio Sampaio 2020-02-16 05:01
- crap Helmut 2020-02-15 17:53
- Brainless copy-and-paste-devil Helmut 2020-02-12 02:26
- EU, method C preference ElMaestro 2019-10-11 10:25
- On the contrary, my dear Dr. Watson! Helmut 2019-10-11 11:52
- On the contrary, my dear Dr. Watson! nobody 2019-10-11 17:39
- On the contrary, my dear Dr. Watson! Helmut 2019-10-11 17:47
- On the contrary, my dear Dr. Watson! ElMaestro 2019-10-11 18:01
- On the contrary, my dear Dr. Watson! nobody 2019-10-11 18:08
- On the contrary, my dear Dr. Watson! Helmut 2019-10-11 18:11
- On the contrary, my dear Dr. Watson! ElMaestro 2019-10-11 18:01
- On the contrary, my dear Dr. Watson! Helmut 2019-10-11 17:47
- On the contrary, my dear Dr. Watson! nobody 2019-10-11 17:39
- EU: simulation-based methods in agony Helmut 2019-10-19 12:38
- EU: ABEL TIE?? mittyri 2019-10-19 23:24
- Reference-scaling: only simulations possible Helmut 2019-10-20 13:58
- EU: ABEL TIE?? mittyri 2019-10-19 23:24
- On the contrary, my dear Dr. Watson! Helmut 2019-10-11 11:52
- Appropriate wording for a protocol Elena777 2019-09-09 19:34
- Appropriate wording for a protocol ElMaestro 2019-09-09 21:39
- Appropriate wording for a protocol Helmut 2019-09-09 23:27
- Appropriate wording for a protocol Ohlbe 2019-09-10 10:27
- Which country? Helmut 2019-09-09 23:17
- Which country? Elena777 2019-09-11 20:24
- EEU-rules, TSD-methods (lengthy answer) Helmut 2019-09-12 01:31
- EEU-rules, TSD-methods (lengthy question) Astea 2019-09-14 14:56
- n2 based on PK metric with higher CV Helmut 2019-09-16 11:50
- Q&A ref Astea 2019-09-16 18:28
- The omniscient oracle has spoken Helmut 2019-09-17 12:27
- The omniscient oracle has spoken Astea 2019-09-17 20:34
- OT: Булга́ков Helmut 2019-09-18 12:12
- The omniscient oracle has spoken Astea 2019-09-17 20:34
- The omniscient oracle has spoken Helmut 2019-09-17 12:27
- n2 based on PK metric with higher CV Elena777 2019-09-16 19:48
- AUC passes with 0.05 and Cmax with 0.0294 Helmut 2019-09-16 23:30
- AUC passes with 0.05 and Cmax with 0.0294 Mikalai 2019-09-18 16:56
- Hybrid B/C Helmut 2019-09-18 17:09
- AUC passes with 0.05 and Cmax with 0.0294 Elena777 2019-09-19 08:34
- Use data of all dosed subjects Helmut 2019-09-19 15:16
- Use data of all dosed subjects Elena777 2019-09-19 15:27
- ‘Method C’ ⇒ risky Helmut 2019-09-19 16:15
- Use data of all dosed subjects Elena777 2019-09-19 15:27
- Use data of all dosed subjects Helmut 2019-09-19 15:16
- AUC passes with 0.05 and Cmax with 0.0294 Mikalai 2019-09-18 16:56
- AUC passes with 0.05 and Cmax with 0.0294 Helmut 2019-09-16 23:30
- Q&A ref Astea 2019-09-16 18:28
- EEU-rules, TSD-methods (lengthy question) Elena777 2019-09-16 19:35
- apple tree for two-stage Astea 2019-09-16 20:39
- overripe apples Helmut 2019-09-16 23:37
- override apples Astea 2019-09-17 06:14
- overripe apples Helmut 2019-09-16 23:37
- apple tree for two-stage Astea 2019-09-16 20:39
- n2 based on PK metric with higher CV Helmut 2019-09-16 11:50
- EEU-rules, TSD-methods (lengthy question) Astea 2019-09-14 14:56
- EEU-rules, TSD-methods (lengthy answer) Helmut 2019-09-12 01:31
- Which country? Elena777 2019-09-11 20:24
- Appropriate wording for a protocol ElMaestro 2019-09-09 21:39
- Two-Stage Design for FDC Astea 2019-06-06 01:24
- No simple way out mittyri 2019-06-08 15:44
- the more complicated the more interesting Astea 2019-06-09 22:56
- No simple way out mittyri 2019-06-08 15:44
- 2-stage design with interim sample size estimation d_labes 2010-10-05 15:09
- 2-stage design with interim sample size estimation Jack 2010-10-25 18:20
- Null = bioINequivalence Helmut 2010-10-25 19:16
- 2-stage design with interim sample size estimation d_labes 2010-10-26 13:28
- 2-stage design with interim sample size estimation Jack 2010-10-26 18:26
- Blind or not, Indecisions or Decisions d_labes 2010-10-27 16:01
- Blind or not, Indecisions or Decisions Jack 2010-10-27 18:14
- Blind ? Ohlbe 2010-10-27 23:37
- Blind ? Jack 2010-10-28 10:24
- Blind 2Stage Astea 2019-05-30 10:37
- Blind 2Stage Helmut 2019-05-30 12:56
- Blind 2Stage and an elephant Astea 2019-05-31 14:36
- Which elephant? Helmut 2019-06-02 20:14
- Blind interim in parallel design? Astea 2019-06-03 01:47
- Blind men d_labes 2019-06-05 12:23
- The Blind Leading the Blind Astea 2019-06-06 00:55
- Blind men d_labes 2019-06-05 12:23
- Blind interim in parallel design? Astea 2019-06-03 01:47
- Which elephant? Helmut 2019-06-02 20:14
- Blind 2Stage and an elephant Astea 2019-05-31 14:36
- Blind 2Stage Helmut 2019-05-30 12:56
- Blind 2Stage Astea 2019-05-30 10:37
- Blind ? Jack 2010-10-28 10:24
- Blind ? Ohlbe 2010-10-27 23:37
- Blind or not, Indecisions or Decisions Jack 2010-10-27 18:14
- Blind or not, Indecisions or Decisions d_labes 2010-10-27 16:01
- 2-stage design with interim sample size estimation Jack 2010-10-26 18:26
- 2-stage design with interim sample size estimation Jack 2010-10-25 18:20
- Finally: Exact TSD methods for 2×2 crossover designs Helmut 2018-04-21 17:17
- Exact TSD methods: Example Helmut 2018-04-21 20:33
- Finally: Exact TSD methods for 2×2 crossover designs ElMaestro 2018-04-21 20:49
- Flow chart (without details) Helmut 2018-04-21 21:41
- naive questions regarding new functions in Power2Stage mittyri 2018-04-28 15:54
- Some answers Helmut 2018-04-28 17:29
- Some more "answers" d_labes 2018-04-29 21:11
- clarification regarding user Power2Stage guides mittyri 2018-04-30 13:41
- naive questions regarding new functions in Power2Stage mittyri 2018-04-28 15:54
- Flow chart (without details) Helmut 2018-04-21 21:41
- Technicality: Weigths for the inverse normal approach d_labes 2018-04-25 14:19
- Selection of w and w* Helmut 2018-04-26 09:51
- Selection of w and w* d_labes 2018-04-26 20:02
- Now what? w & w* examples d_labes 2018-05-09 13:53
- Now what? w & w* examples Ben 2018-06-10 20:12
- Now what? w & w* examples Helmut 2018-06-11 13:57
- Now what? w & w* examples Ben 2018-06-12 19:14
- a bug in interim.tsd.in()? mittyri 2018-06-11 23:27
- a bug in interim.tsd.in()? Ben 2018-06-12 19:32
- Nonbinding futility rule d_labes 2018-06-13 16:59
- Bad weather? Helmut 2018-06-13 19:23
- NLYW? d_labes 2018-06-14 10:18
- Nonbinding futility rule Ben 2018-06-13 20:26
- Nonbinding futility rule d_labes 2018-06-14 10:47
- Nonbinding futility rule Ben 2018-06-15 17:58
- Binding / Nonbinding futility rule - alpha control d_labes 2018-06-16 19:42
- Binding / Nonbinding futility rule - alpha control Ben 2019-03-30 09:52
- Binding / Nonbinding futility rule - alpha control d_labes 2018-06-16 19:42
- Nonbinding futility rule Ben 2018-06-15 17:58
- Nonbinding futility rule d_labes 2018-06-14 10:47
- Bad weather? Helmut 2018-06-13 19:23
- Nonbinding futility rule d_labes 2018-06-13 16:59
- a bug in interim.tsd.in()? Ben 2018-06-12 19:32
- Now what? w & w* examples Helmut 2018-06-11 13:57
- Now what? w & w* examples Ben 2018-06-10 20:12
- Selection of w and w* Helmut 2018-04-26 09:51
- Two-stage design and 'forced bioequivalence' Mikalai 2018-06-06 08:28
- Two-stage design and 'forced bioequivalence' ElMaestro 2018-06-06 10:53
- Two-stage design and 'forced bioequivalence' Yura 2018-06-07 10:24
- But what is the real problem? ElMaestro 2018-06-07 13:53
- But what is the real problem? Yura 2018-06-07 14:59
- But what is the real problem? Mikalai 2018-06-07 15:47
- But what is the real problem? Helmut 2018-06-07 17:33
- But what is the real problem? Mikalai 2018-06-08 12:24
- U as a futility criterion Helmut 2018-06-08 14:00
- But what is the real problem? Mikalai 2018-06-08 12:24
- But what is the real problem? Helmut 2018-06-07 17:33
- But what is the real problem? Mikalai 2018-06-07 15:47
- But what is the real problem? Yura 2018-06-07 14:59
- But what is the real problem? ElMaestro 2018-06-07 13:53
- Two-stage design and 'forced bioequivalence' Yura 2018-06-07 10:24
- Two-stage design and 'forced bioequivalence' ElMaestro 2018-06-06 10:53
- Two PK metrics: Inflation of the Type I Error Helmut 2017-11-12 11:57
- Two PK metrics: Inflation of the Type I Error? d_labes 2017-11-12 17:46
- A place to start ElMaestro 2017-11-12 21:43
- A place to start? d_labes 2017-11-13 16:02
- A place to start? Helmut 2017-11-13 16:51
- Scientific gut feeling d_labes 2017-11-15 10:34
- Five minutes gone - power.tsd.2m() arose d_labes 2017-11-15 13:15
- Scientific gut feeling d_labes 2017-11-15 10:34
- A better place to start. ElMaestro 2017-11-14 00:04
- Nope Helmut 2017-11-14 00:21
- Nope nobody 2017-11-14 08:11
- I've meditated hard ElMaestro 2017-11-14 12:41
- Nope Helmut 2017-11-14 00:21
- A place to start? Helmut 2017-11-13 16:51
- A place to start? d_labes 2017-11-13 16:02
- Potvin designs w. imbalance - what would you expect? ElMaestro 2017-08-17 13:02
- Dropouts in stage 2 Helmut 2017-09-12 01:41
- Dropouts continued Helmut 2017-09-19 17:17
- Initial sample size guess for the Potvin methods ElMaestro 2017-08-19 15:04
- Initial sample size guess for the Potvin methods Helmut 2017-08-19 16:06
- Initial sample size guess for the Potvin methods ElMaestro 2017-08-19 16:14
- Initial sample size guess for the Potvin methods Helmut 2017-08-19 17:12
- Initial sample size guess for the Potvin methods ElMaestro 2017-08-19 17:17
- Confuse-a-Cat Helmut 2017-08-19 17:33
- Confuse-a-Cat ElMaestro 2017-08-19 17:56
- Confuse-a-Cat Helmut 2017-08-19 17:33
- Initial sample size guess for the Potvin methods ElMaestro 2017-08-19 17:17
- loop ↔ vectorized ↔ direct Helmut 2017-08-20 14:40
- loop ↔ vectorized ↔ direct ElMaestro 2017-08-20 15:22
- loop ↔ vectorized ↔ direct Helmut 2017-08-20 16:23
- loop ↔ vectorized ↔ direct ElMaestro 2017-08-20 17:22
- loop ↔ vectorized ↔ direct Helmut 2017-08-20 16:23
- loop ↔ vectorized ↔ direct ElMaestro 2017-08-20 15:22
- Initial sample size guess for the Potvin methods Helmut 2017-08-19 17:12
- Initial sample size guess for the Potvin methods ElMaestro 2017-08-19 16:14
- The n ext crackpot iteration ElMaestro 2017-08-19 20:04
- The n ext crackpot iteration Helmut 2017-08-20 02:20
- The ultimate crackpot iteration! ElMaestro 2017-08-20 14:35
- The ultimate crackpot iteration! Helmut 2017-08-20 15:11
- The ultimate crackpot iteration! ElMaestro 2017-08-20 15:28
- The ultimate crackpot iteration! Helmut 2017-08-20 16:06
- The ultimate crackpot iteration! ElMaestro 2017-08-20 16:15
- The ultimate crackpot iteration! Helmut 2017-08-20 18:58
- The ultimate crackpot iteration! ElMaestro 2017-08-20 19:32
- Suggested code ElMaestro 2017-08-21 18:13
- Nitpicker! Helmut 2017-08-22 13:33
- Nitpicker! ElMaestro 2017-08-22 17:27
- Nitpicker! Helmut 2017-08-22 17:49
- Nitpicker! ElMaestro 2017-08-22 17:59
- Nitpicker! Helmut 2017-08-22 19:15
- Benchmark code ElMaestro 2017-08-22 22:29
- Benchmark code Helmut 2017-08-23 01:48
- Benchmark code ElMaestro 2017-08-22 22:29
- Nitpicker! Helmut 2017-08-22 19:15
- Nitpicker! ElMaestro 2017-08-22 17:59
- Nitpicker! Helmut 2017-08-22 17:49
- Nitpicker! ElMaestro 2017-08-22 17:27
- Nitpicker! Helmut 2017-08-22 13:33
- Suggested code ElMaestro 2017-08-21 18:13
- The ultimate crackpot iteration! ElMaestro 2017-08-20 19:32
- The ultimate crackpot iteration! Helmut 2017-08-20 18:58
- The ultimate crackpot iteration! ElMaestro 2017-08-20 16:15
- The ultimate crackpot iteration! Helmut 2017-08-20 16:06
- The ultimate crackpot iteration! ElMaestro 2017-08-20 15:28
- The ultimate crackpot iteration! Helmut 2017-08-20 15:11
- Initial sample size guess for the Potvin methods Helmut 2017-08-19 16:06
- Potvin C in the EU Helmut 2013-04-16 17:40
- Potvin C in the EU ElMaestro 2013-04-17 02:31
- Potvin C in the EU Helmut 2013-04-17 12:23
- 2 Groups model FDA d_labes 2013-04-17 13:10
- 2 Groups model FDA Helmut 2013-04-17 16:37
- Group effects obsolete? d_labes 2013-04-18 09:55
- Group effects FDA/EMA Helmut 2013-04-19 14:34
- Group effects FDA/EMA mittyri 2014-08-21 15:34
- Group effects FDA/EMA ElMaestro 2014-08-21 17:31
- Group effects EMA mittyri 2014-10-01 11:25
- Group effects EMA ElMaestro 2014-10-01 11:31
- Group effects EMA Helmut 2014-10-01 13:24
- Group effects EMA VStus 2016-10-06 22:06
- Group effects EMA ElMaestro 2016-10-07 12:45
- Group effects EMA mittyri 2016-10-07 15:06
- Fixed effects model with Group term mittyri 2016-10-09 13:27
- Fixed effects model: changing the F, p values mittyri 2016-10-10 18:33
- Fixed effects model: changing the F, p values ElMaestro 2016-10-10 20:10
- Fixed effects model: changing the F, p values Helmut 2016-10-11 00:17
- Holy War of type III d_labes 2016-10-11 13:17
- Significance of Group effect in Russia: why the type III is so 'important' mittyri 2016-10-11 15:07
- Fixed effects model: changing the F, p values zizou 2016-10-11 01:06
- FDA group model in R mittyri 2016-10-11 13:43
- FDA group model in R ElMaestro 2016-10-12 01:07
- FDA group model in R VStus 2016-10-17 15:32
- FDA group model in R ElMaestro 2016-10-17 18:58
- FDA group model in R VStus 2016-10-20 13:57
- FDA group model in R ElMaestro 2016-10-17 18:58
- FDA group model in R mittyri 2016-10-11 13:43
- Fixed effects model: changing the F, p values ElMaestro 2016-10-10 20:10
- Fixed effects model with Group term VStus 2016-10-20 13:54
- Fixed effects model: changing the F, p values mittyri 2016-10-10 18:33
- Fixed effects model with Group term mittyri 2016-10-09 13:27
- Group effects EMA mittyri 2016-10-07 15:06
- Group effects EMA ElMaestro 2016-10-07 12:45
- Group effects EMA VStus 2016-10-06 22:06
- Group effects FDA/EMA zizou 2016-12-31 02:54
- Group effects FDA/EMA Helmut 2017-06-03 14:57
- Group effects EMA mittyri 2014-10-01 11:25
- Group effects FDA/EMA ElMaestro 2014-08-21 17:31
- Group effects FDA/EMA mittyri 2014-08-21 15:34
- Group effects FDA/EMA Helmut 2013-04-19 14:34
- 2 Groups model FDA hiren379 2013-08-22 14:32
- Homework Helmut 2013-08-23 11:53
- Group effects obsolete? d_labes 2013-04-18 09:55
- 2 Groups model FDA Helmut 2013-04-17 16:37
- 2 Groups model FDA d_labes 2013-04-17 13:10
- Potvin C in the EU Helmut 2013-04-17 12:23
- Potvin C in the EU ElMaestro 2013-04-17 02:31
- Data for 2nd stage of Potvin’s designs BE-proff 2017-02-18 06:40
- Data for 2nd stage of Potvin’s designs ElMaestro 2017-02-18 10:20
- Data for 2nd stage of Potvin’s designs BE-proff 2017-02-18 13:29
- GMR = fixed! Helmut 2017-02-18 16:23
- Data for 2nd stage of Potvin’s designs BE-proff 2017-02-18 13:29
- “Type 1” slightly higher power than “Type 2” for the same adj. α Helmut 2017-02-18 11:51
- “Type 1” slightly higher power than “Type 2” for the same adj. α BE-proff 2017-02-18 13:31
- Terminology Helmut 2017-02-18 16:27
- Terminology Yura 2017-02-20 11:28
- Which GMR to plug in ElMaestro 2017-02-20 11:46
- Which GMR to plug in BE-proff 2017-02-21 11:35
- Which GMR to plug in ElMaestro 2017-02-21 11:47
- Which GMR to plug in BE-proff 2017-02-21 11:35
- Validated frameworks; observed GMR not relevant Helmut 2017-02-22 12:03
- Validated frameworks; observed GMR not relevant Silva 2017-03-09 01:26
- GMR, theta 0 and that all d_labes 2017-03-09 09:21
- GMR, theta 0 and that all Silva 2017-03-09 12:38
- GMR, theta 0 and that all ElMaestro 2017-03-09 12:56
- GMR, theta0 and that all d_labes 2017-03-09 13:55
- GMR, theta0 and that all Silva 2017-03-09 18:01
- GMR, theta 0 and that all Silva 2017-03-09 12:38
- GMR, theta 0 and that all d_labes 2017-03-09 09:21
- Validated frameworks; observed GMR not relevant Silva 2017-03-09 01:26
- Which GMR to plug in ElMaestro 2017-02-20 11:46
- Terminology Yura 2017-02-20 11:28
- Terminology Helmut 2017-02-18 16:27
- “Type 1” slightly higher power than “Type 2” for the same adj. α BE-proff 2017-02-21 11:31
- “Type 1” slightly higher power than “Type 2” for the same adj. α BE-proff 2017-02-18 13:31
- Data for 2nd stage of Potvin’s designs ElMaestro 2017-02-18 10:20