Bioequivalence and Bioavailability Forum • Opinion yes, answer no

Opinion yes, answer no [Two-Stage / GS Designs]

posted by ElMaestro – Denmark, 2011-10-26 13:15 (5360 d 06:58 ago) – Posting: # 7544
Views: 21,752

Dear d_labes,

❝ (...) the power check step is complementary to the sample size adaptation step.

I tried to imagine what a decision tree could look like in the absence of a power evaluation. I did not come up with much useful. The ideal design imho minimises type I errors and maximises power (=minimises futility), generally. By all means, if you have a proposal for a scheme that works somehow without the power step then I think it would be worth publishing. There is too much interest in this topic and too few publication out there to let such an opportunity pass unnoticed.

Best regards,
EM.

Complete thread:

2-stage design - power evaluation d_labes 2011-10-12 11:10 [Two-Stage / GS Designs]
- No opinions out there? d_labes 2011-10-26 09:14
  - Opinion yes, answer noElMaestro 2011-10-26 11:15
    - Decision scheme without (?) power check d_labes 2011-10-26 13:00
      - Decision scheme without (?) power check ElMaestro 2011-10-26 13:20
        
        Decision scheme 'without' power check d_labes 2011-10-26 14:51
        
        Decision scheme 'without' power check ElMaestro 2011-10-26 15:24
        
        Numerical example d_labes 2011-10-26 16:28
        
        Numerical example ElMaestro 2011-10-26 16:49
        
        Potvin C with unsymmetrical alphas d_labes 2011-10-27 14:54
        
        Potvin B, C, or D? Helmut 2011-10-27 22:52
        Two-stage (classical Pocock) and the FDA Helmut 2011-10-31 02:36
- Weirdo paper ElMaestro 2011-11-30 18:04
  - Weirdo paper Helmut 2011-11-30 23:45
    - Weirdo paper ElMaestro 2011-12-01 07:16