Bioequivalence and Bioavailability Forum • Inter and Total Variability

Inter and Total Variability [Power / Sample Size]

posted by Ben – Germany, 2011-09-02 15:43 (5409 d 09:53 ago) – Posting: # 7327
Views: 18,400

Dear all,

I looked at the presentation slides about sample size calculations from HS, see here. There's a formula for the inter CV (slide #8) and I do not quite understand why the exponent from the exponential is the difference of MSE_B and MSE_W divided by 2 (and not just MSE_B). Would be great if someone could give me some more details on that.
Also I read that one only gets the total variance out from a parallel study. The reason for that is what? Is it just the fact that the intra subject variability always exists, but cannot be measured by this kind of design?

Thank you in advance for clarification.

Best regards,
Benjamin

Edit: Moved to a category which fits the topic better, IMHO. [Helmut]

Complete thread:

Inter and Total VariabilityBen 2011-09-02 13:43 [Power / Sample Size]
- Inter and Total Variability Helmut 2011-09-02 14:21
  - Inter and Total Variability Ben 2011-09-03 11:28
    - Inter and Total Variability Ben 2011-09-08 19:22
      - Inter and Total Variability Helmut 2011-09-11 11:55
        
        Inter and Total Variability Ben 2011-09-13 22:03
        
        Inter and Total Variability Helmut 2011-09-14 00:43
        
        Inter and Total Variability Ben 2011-09-18 12:36
        Inter and Total Variability Ben 2011-10-06 18:51
        
        Inter-subject variance sasophylistic (GLM vs. MIXED) d_labes 2011-10-07 13:33
      - Inter and Total Variability ElMaestro 2011-09-18 14:14
        
        Inter and Total Variability Ben 2011-09-19 19:43