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RegisterIntra Subject Variability [Power / Sample Size]
Hello Alpesh Ramani,
Both.
There is no easy answer. I would use the CV-value that appears most trustworthy from your source material. Age of study, apparent standard of conduct, and N would all play a role. I would not pool studies, but that of course is a personal and subjective comment.
❝ Intrasubject CV is molecule property or its' also affected by formulation property?
Both.
❝ As everybody know that % CV is used to calculate the sample size. So it is always a matter of confusion with % CV take for sample size calculation for next study, i.e., First pilot, recent study or literature based CV.
There is no easy answer. I would use the CV-value that appears most trustworthy from your source material. Age of study, apparent standard of conduct, and N would all play a role. I would not pool studies, but that of course is a personal and subjective comment.
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Pass or fail!
ElMaestro
Pass or fail!
ElMaestro
Complete thread:
- Intra Subject Variability Phaneendra.K 2011-03-10 12:39 [Power / Sample Size]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Intra Subject Variability Helmut 2011-03-10 12:50
- Intra Subject Variability Alpesh Ramani 2011-03-14 09:10
- Intra Subject VariabilityElMaestro 2011-03-14 09:19
- Intra Subject Variability Alpesh Ramani 2011-03-14 09:10
- Intra Subject Variability Helmut 2011-03-10 12:50
Ing. Helmut Schütz