Gambling with UN [RSABE / ABEL]
Dear ElMaestro,
Don't be so lightheaded with your money. The first million is the difficilest
.
For the ABE evaluation (Proc MIXED code) the FDA statistics guideline recommends FA0(2). And then "... In the Random statement, TYPE=FA0(2) could possibly be replaced by TYPE=CSH. This guidance recommends that TYPE=UN not be used, as it could result in an invalid (i.e., not nonnegative definite) estimated covariance matrix ...". Sic!
But if we look at the results via intra-subject contrast for the Scaled ABE evaluation it seems that this estimation method is implicit an UN evaluation.
What I really don't understand in case of a full replicate study (4-period study) why not use the results of the ABE code and then do the calculations for the scaled BE criterion?! All necessary terms are at hand, point estimate of T-R with CI (or SD), intra-subject sWR.
Ok, for the extra-reference design we don't have a working code via Proc MIXED.
❝ I think I will bet my money on CSH for future applications ("but the guideline says....").
Don't be so lightheaded with your money. The first million is the difficilest

For the ABE evaluation (Proc MIXED code) the FDA statistics guideline recommends FA0(2). And then "... In the Random statement, TYPE=FA0(2) could possibly be replaced by TYPE=CSH. This guidance recommends that TYPE=UN not be used, as it could result in an invalid (i.e., not nonnegative definite) estimated covariance matrix ...". Sic!
But if we look at the results via intra-subject contrast for the Scaled ABE evaluation it seems that this estimation method is implicit an UN evaluation.
What I really don't understand in case of a full replicate study (4-period study) why not use the results of the ABE code and then do the calculations for the scaled BE criterion?! All necessary terms are at hand, point estimate of T-R with CI (or SD), intra-subject sWR.

Ok, for the extra-reference design we don't have a working code via Proc MIXED.
—
Regards,
Detlew
Regards,
Detlew
Complete thread:
- Reference scaled BE - FDA (and FARTSSIE update) ddubins 2010-04-26 20:28 [RSABE / ABEL]
- Reference scaled ABE - FDA d_labes 2010-04-27 08:58
- Reference scaled ABE - FDA ElMaestro 2010-04-27 13:39
- Factor 2 is unbiased d_labes 2010-04-27 14:30
- Biased bonus from MoM d_labes 2010-05-04 12:10
- Biased bonus from MoM ElMaestro 2010-05-04 12:54
- Mixed MoM d_labes 2010-05-04 14:40
- Mixed MoM ElMaestro 2010-05-04 15:08
- R and G, CSH and UN d_labes 2010-05-05 10:42
- A sailor gets confused ElMaestro 2010-05-05 11:49
- Confused V/Z matratzen and tips d_labes 2010-05-05 14:49
- superb post! ElMaestro 2010-05-05 21:32
- Gambling with UNd_labes 2010-05-06 11:00
- superb post! ElMaestro 2010-05-05 21:32
- Confused V/Z matratzen and tips d_labes 2010-05-05 14:49
- A sailor gets confused ElMaestro 2010-05-05 11:49
- R and G, CSH and UN d_labes 2010-05-05 10:42
- Mixed MoM yjlee168 2010-05-05 09:12
- Mixed MoM ElMaestro 2010-05-04 15:08
- Mixed MoM d_labes 2010-05-04 14:40
- Biased bonus from MoM ElMaestro 2010-05-04 12:54
- Reference scaled ABE - FDA ElMaestro 2010-04-27 13:39
- Reference scaled BE - FDA (and FARTSSIE update) KR 2010-04-27 13:14
- Reference scaled BE - EMA Helmut 2010-04-27 14:58
- Reference scaled BE - EMA ddubins 2010-04-27 17:52
- Partial replicate design and FDA ABE code d_labes 2010-04-28 09:47
- Reference scaled BE - EMA Helmut 2010-04-28 14:46
- Switching - null sWR d_labes 2010-05-04 14:04
- Reference scaled BE - EMA ddubins 2010-04-27 17:52
- The unknown x d_labes 2010-05-06 13:26
- The unknown x jdetlor 2010-09-28 17:22
- Unknown x corrected? d_labes 2010-10-01 12:14
- Unknown x corrected? Qilex 2016-09-21 12:25
- Official unknown x d_labes 2016-09-21 13:22
- Unknown x corrected? Qilex 2016-09-21 12:25
- Unknown x corrected? d_labes 2010-10-01 12:14
- The unknown x jdetlor 2010-09-28 17:22
- Reference scaled ABE - FDA d_labes 2010-04-27 08:58