Bioequivalence and Bioavailability Forum • Factor 2 is unbiased

Factor 2 is unbiased [RSABE / ABEL]

posted by d_labes – Berlin, Germany, 2010-04-27 16:30 (5481 d 02:09 ago) – Posting: # 5248
Views: 36,176

Dear sailor and simulant,

❝ But what about this (page 5, emphasis in red by me):

❝ From the dataset DGLM1, calculate the following:

❝ DGLM1: dfd=df;

❝ s2wr=ms/2;

❝

❝ Do you know how/what/why?

Here the analysis covers the differences R1-R2 which has expected variance =2*sigma²_WR.
The trick of the GLM call (diffs versus sequence) gives the MS of R1-R2 "stratified" over the sequences (double sum in the formula for s²_WR in step 1 on page 2 divided by (n-m)). You can verify this by conventional calculation.

Since I have answered your question I'm exempted from answering the bonus questions :-D

.
To be honest: I don't know exactly. But I conjecture: Yes in balanced design without missings.

—
Regards,

Detlew

Complete thread:

Reference scaled BE - FDA (and FARTSSIE update) ddubins 2010-04-26 20:28 [RSABE / ABEL]
- Reference scaled ABE - FDA d_labes 2010-04-27 08:58
  - Reference scaled ABE - FDA ElMaestro 2010-04-27 13:39
    - Factor 2 is unbiasedd_labes 2010-04-27 14:30
    - Biased bonus from MoM d_labes 2010-05-04 12:10
      - Biased bonus from MoM ElMaestro 2010-05-04 12:54
        
        Mixed MoM d_labes 2010-05-04 14:40
        
        Mixed MoM ElMaestro 2010-05-04 15:08
        
        R and G, CSH and UN d_labes 2010-05-05 10:42
        
        A sailor gets confused ElMaestro 2010-05-05 11:49
        
        Confused V/Z matratzen and tips d_labes 2010-05-05 14:49
        
        superb post! ElMaestro 2010-05-05 21:32
        
        Gambling with UN d_labes 2010-05-06 11:00
        
        Mixed MoM yjlee168 2010-05-05 09:12
- Reference scaled BE - FDA (and FARTSSIE update) KR 2010-04-27 13:14
- Reference scaled BE - EMA Helmut 2010-04-27 14:58
  - Reference scaled BE - EMA ddubins 2010-04-27 17:52
    - Partial replicate design and FDA ABE code d_labes 2010-04-28 09:47
    - Reference scaled BE - EMA Helmut 2010-04-28 14:46
    - Switching - null sWR d_labes 2010-05-04 14:04
- The unknown x d_labes 2010-05-06 13:26
  - The unknown x jdetlor 2010-09-28 17:22
    - Unknown x corrected? d_labes 2010-10-01 12:14
      - Unknown x corrected? Qilex 2016-09-21 12:25
        
        Official unknown x d_labes 2016-09-21 13:22