Reference scaled ABE - FDA [RSABE / ABEL]

posted by ElMaestro  – Denmark, 2010-04-27 15:39 (5531 d 13:29 ago) – Posting: # 5247
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Dear dlabes and all,

❝ BTW2: It is not clear why they recommend Proc MIXED in case of fully replicate design and Proc GLM in case of partial replicate.


Perhaps they also could not specify a Mixed Model where a intra-Ref sigma could be derived where replicated Test is not available? I wonder if SAS has this ability for partial repliacted studies at all.

But what about this (page 5, emphasis in red by me):
From the dataset DGLM1, calculate the following:
DGLM1: dfd=df;
s2wr=ms/2;


Do you know how/what/why? I am not readily able to understand where it comes from or why this would work, but I would think this is the modeled equivalent of the Swr calculation in step 1 (?).


Bonus questions:
1. Is the estimated Swr unbiased?
2. If yes, is it even reflecting max likelihood?

Best regards
EM - sailor and simulant.

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