Bioequivalence and Bioavailability Forum • Sample size for a pilot study to estimate the CVintra

Sample size for a pilot study to estimate the CVintra [Power / Sample Size]

posted by yjlee168 – Kaohsiung, Taiwan, 2010-03-04 23:35 (5550 d 20:34 ago) – Posting: # 4863
Views: 13,079

Dear Helmut,

Thanks again for your response.

❝ variability. I'm afraid, there is not a simple answer to the question above.

Agree.

❝ ❝ Uhh... Sorry about that I don't know how to interpret/use this table.

❝ That's easy. You have a pilot study (n=4) which gave you a CV of 20%

I see. Great.

❝ I'm not sure whether I understand this procedure. Sounds like some kind of resampling (bootstraping), but I don't get the point. Why 24? Bootstraping

Kind of, but it's absolutely not.

❝ Well, easy question - difficult answer. I'm really in favour of sequential designs; you guessed right: D Potvin et al. (2008) is my favourite method.

Well, thanks to ElMaestro too. After I got the replied message from EM, I did some search and found some nice articles regarding adaptive two-stage desing with pilot-pivotal trials for average BE. I think the optimal design of a average BE pilot study is an important issue, although we do not see many investigators published the results of their pilot study. Probably it's kind of trivial as you said.

—
All the best,
-- Yung-jin Lee
bear v2.9.2:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan https://www.pkpd168.com/bear
Download link (updated) -> here

Complete thread:

Sample Size BA/BE Sriraj 2010-02-26 14:32 [Power / Sample Size]
- Sample Size BA/BE Helmut 2010-03-01 14:00
  - Sample size for a pilot study to estimate the CVintra yjlee168 2010-03-01 19:25
    - Sample size for a pilot study to estimate the CVintra Helmut 2010-03-01 21:01
      - Sample size for a pilot study to estimate the CVintra yjlee168 2010-03-01 23:47
        
        Sample size for a pilot study to estimate the CVintra Helmut 2010-03-03 19:04
        
        Sample size for a pilot study to estimate the CVintrayjlee168 2010-03-04 22:35
      - 80% confidence ? d_labes 2010-03-19 13:02
        
        75% confidence... Helmut 2010-03-19 14:12
    - Sample size for a pilot study to estimate the CVintra ElMaestro 2010-03-01 22:23
      - Sample size for a pilot study to estimate the CVintra yjlee168 2010-03-02 00:02
      - Sample size for a pilot study to estimate the CVintra Helmut 2010-03-02 02:19
        
        Sample size for a pilot study to estimate the CVintra yjlee168 2010-03-29 13:27
        
        Sample size for a pilot study to estimate the CVintra ElMaestro 2010-03-29 13:39
        
        Sample size for a pilot study to estimate the CVintra yjlee168 2010-03-29 13:47
        
        Sequential designs (history and future) Helmut 2010-03-29 14:19
        
        Sequential designs (history and future) yjlee168 2010-03-29 19:19
        
        Sequential designs (history and future) Helmut 2010-03-29 20:43
        
        Sequential designs (history and future) yjlee168 2010-04-01 18:58
        
        Sequential designs (WinNonlin vs. bear) Helmut 2010-04-02 21:00