Bioequivalence and Bioavailability Forum • Sample size for PK linearity

Sample size for PK linearity [Power / Sample Size]

posted by ElMaestro – Denmark, 2009-05-26 19:26 (5822 d 09:15 ago) – Posting: # 3767
Views: 19,038

Dear HS,

❝ α>0 and β≠0, weighted regression (w = 1/x)

Could you explain where that weight comes from? I would intuitively say it should be non-weighted, as nonlinearity can easily be e.g. a phenomenon only visible/measurable in the upper dose region. In this case I would think this weight would work against the chance of finding it.

EM.

Complete thread:

Sample size for PK linearity Kro 2009-05-19 10:56 [Power / Sample Size]
- Sample size for PK linearity Helmut 2009-05-19 13:19
  - Sample size for PK linearity Kro 2009-05-19 13:56
    - Sample size for PK linearity Helmut 2009-05-19 15:09
      - Sample size for PK linearityElMaestro 2009-05-26 17:26
        
        Weighting scheme Helmut 2009-05-26 19:52
      - Sample size for PK linearity mjons 2011-12-08 18:03
      - Sample size for PK linearity Lucas 2014-09-11 21:41
        
        Sample size for PK linearity - power model d_labes 2014-09-12 15:01
        
        Power dose proportionality - power model - Correction d_labes 2014-10-01 09:09
        
        Sample size for PK linearity d_labes 2014-09-13 15:05
        
        Sample size for PK linearity Lucas 2014-10-13 20:36
        
        Sample size for PK linearity d_labes 2014-10-14 09:26
        
        Sample size for PK linearity Lucas 2014-10-14 15:24
  - dose proportionality vs. dose linearity martin 2009-05-25 08:46
    - dose proportionality vs. dose linearity Helmut 2009-05-25 14:59