Bioequivalence and Bioavailability Forum • dose proportionality vs. dose linearity

dose proportionality vs. dose linearity [Power / Sample Size]

posted by martin – Austria, 2009-05-25 10:46 (5870 d 04:22 ago) – Posting: # 3745
Views: 20,305

Dear HS !

I think you mixed up dose-linearity and dose-proportionality.

Dose-proportionality: doubling of the dose within this range leads to doubling of Cmax or AUC (e.g. Cawello, 2003; page 149).

Using the power-law model AUC = a × Dose^b, dose-proportionality holds when b = 1 (straight line through origin) and dose-proportionality implies dose-linearity but not vice versa.

best regards

Martin

Complete thread:

Sample size for PK linearity Kro 2009-05-19 10:56 [Power / Sample Size]
- Sample size for PK linearity Helmut 2009-05-19 13:19
  - Sample size for PK linearity Kro 2009-05-19 13:56
    - Sample size for PK linearity Helmut 2009-05-19 15:09
      - Sample size for PK linearity ElMaestro 2009-05-26 17:26
        
        Weighting scheme Helmut 2009-05-26 19:52
      - Sample size for PK linearity mjons 2011-12-08 18:03
      - Sample size for PK linearity Lucas 2014-09-11 21:41
        
        Sample size for PK linearity - power model d_labes 2014-09-12 15:01
        
        Power dose proportionality - power model - Correction d_labes 2014-10-01 09:09
        
        Sample size for PK linearity d_labes 2014-09-13 15:05
        
        Sample size for PK linearity Lucas 2014-10-13 20:36
        
        Sample size for PK linearity d_labes 2014-10-14 09:26
        
        Sample size for PK linearity Lucas 2014-10-14 15:24
  - dose proportionality vs. dose linearitymartin 2009-05-25 08:46
    - dose proportionality vs. dose linearity Helmut 2009-05-25 14:59