Bioequivalence and Bioavailability Forum • Sample size for PK linearity

Sample size for PK linearity [Power / Sample Size]

posted by Kro – France, 2009-05-19 15:56 (6237 d 15:03 ago) – Posting: # 3703
Views: 21,733

Dear Helmut,

Thanks for your quick answer.
My understanding is that your sample size calculation is based on the BE tests and not on the proportionallity test.
What happens if the principal criteria is the proportionaly test and how to calculate the sample size in this case?

Kindest regards,

Kro

Complete thread:

Sample size for PK linearity Kro 2009-05-19 10:56 [Power / Sample Size]
- Sample size for PK linearity Helmut 2009-05-19 13:19
  - Sample size for PK linearityKro 2009-05-19 13:56
    - Sample size for PK linearity Helmut 2009-05-19 15:09
      - Sample size for PK linearity ElMaestro 2009-05-26 17:26
        
        Weighting scheme Helmut 2009-05-26 19:52
      - Sample size for PK linearity mjons 2011-12-08 18:03
      - Sample size for PK linearity Lucas 2014-09-11 21:41
        
        Sample size for PK linearity - power model d_labes 2014-09-12 15:01
        
        Power dose proportionality - power model - Correction d_labes 2014-10-01 09:09
        
        Sample size for PK linearity d_labes 2014-09-13 15:05
        
        Sample size for PK linearity Lucas 2014-10-13 20:36
        
        Sample size for PK linearity d_labes 2014-10-14 09:26
        
        Sample size for PK linearity Lucas 2014-10-14 15:24
  - dose proportionality vs. dose linearity martin 2009-05-25 08:46
    - dose proportionality vs. dose linearity Helmut 2009-05-25 14:59