Bioequivalence and Bioavailability Forum

Dear Pavan,

❝ We are using Paired equivalence procedure in SAS

What is "paired equivalence procedure in SAS"? Never heard of such a procedure.
The only thing I know is Proc Power (new in SAS 9), which can be used in a wide variety of settings to calculate power or sample size.

❝ [...] My doubt is what ever the software gives is the

❝ final sample size? Or we need to double it?

Ever tried to compare your results with available tables or to recalculate some results of available tables in the literature?

F. i. Diletti, Hauschke, Steinijans,
"Sample size determination for bioequivalence assessment by means of confidence intervals"
Int. J. Clin. Pharmacol. Ther. Toxicol. 30, Suppl. 1, p. S51-58 (1991)

This is some sort of software validation always necessary.

This will also guide you in setting the numerous options in Proc Power, not very well explained (for the un-initiated ) in the documentation, to obtain the desired correct results for your problem.