Sample size prediction [Power / Sample Size]

posted by Helmut Homepage – Vienna, Austria, 2008-11-20 21:52 (6429 d 03:54 ago) – Posting: # 2754
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Dear Ravi!

❝ Can we predict Sample size for 2 x 2 crossover fasted study on the basis

❝ of estimates from a 3 x 3 crossover design [...]


Yes and no. To quote Jaime in this post: 'Obviously 3x3 studies don't die out - but why?'
3x3 designs are flawed, see this post for details.

❝ If yes please tell me the prodecure or formule to be used.


From a study in a 6×3 Williams' design you may calculate CVintra in the usual way as sqrt(exp(MSE)-1) and use it in sample size estimation for the 2×2 study. You may apply the same formula to a 3×3 study as well, but I don't have the slightest idea whether the result is unbiased.

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