Bioequivalence and Bioavailability Forum • extra-reference design: no period effect assumption

extra-reference design: no period effect assumption [RSABE / ABEL]

posted by BEQool – 2025-12-31 17:42 (167 d 13:13 ago) – Posting: # 24546
Views: 1,626

Hey Mittyri,

❝ Yes - for PE under the standard fixed effects model with period (any systematic shift in period 3, R is absorbed by the period 3 effect)

❝ No - for CI (see residual MS and residual df)

Yes of course CI is affected, I wanted to say only PE - thanks!

Thank you for all your answers and explanations, everything is clear now :ok:

:ok:

All the best for the new year :party:

:party:

BEQool

Complete thread:

Partial replicate design Silva 2013-12-31 12:17 [RSABE / ABEL]
- extra-reference design Helmut 2013-12-31 14:28
  - extra-reference design BEQool 2025-12-22 18:27
    - extra-reference design: R code mittyri 2025-12-23 11:58
      - extra-reference design: R code BEQool 2025-12-29 14:17
        
        extra-reference design: no period effect assumption mittyri 2025-12-29 22:16
        
        extra-reference design: no period effect assumptionBEQool 2025-12-31 16:42

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