Bioequivalence and Bioavailability Forum

❝ Have a look at known.designs():

❝     no   design    df df2 steps  bk bknif       bkni                name   

❝      0 parallel   n-2 n-2     2 4.0   1/1 1.00000000         2 parallel groups

❝ ...

❝ 4    2      3x3 2*n-4 n-3     3 2.0   2/9 0.22222222             3x3 crossover

❝ 5    3    3x6x3 2*n-4 n-6     6 2.0  1/18 0.05555556           3x6x3 crossover

❝ ...

❝ 10   9    2x3x3 2*n-3 n-3     3 1.5   1/6 0.16666667 partial replicate (2x3x3)

❝ ...

❝

❝ df are the usual degrees of freedom if you use Proc GLM or equivalent.

Hello all,

firstly, it is good to have BEBAC forum up and running again

I have a question regarding df in partial replicate 2x3x3 design. 44 subjects were included in the PK/STAT analysis - 43 of them had data for all periods while 1 subject had data only for 2 periods (the missing period was with reference treatment B so the subject had data for both treatment A and treatment B). Both in SAS and Phoenix WNL the df of the design (Error) is 84. Why is this so? According to the formula 2*n-3 with 44 subjects included in the analysis, the df should be 2*44-3= 85. Or is this discrepancy (84 vs 85 df) a conseqeunce of one missing period for one subject (although the subject has data for both A and B and is included in the analysis)?

Best regards
BEQool