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RegisterRescue approaching – PowerTOST [Power / Sample Size]
Dear d_labes/Helmut,
In the Vasoconstrictor Assay guide published by the FDA in 1995, a small dataset of AUCE values for the test and reference drugs is provided. The purpose of this dataset is to serve as a numerical example for determining the bioequivalence of these two topical formulations (as part of the main study). At the end of the document, Locke's method is applied, yielding a 90% confidence interval of 53.6–165.9%.
I’ve read on this forum that Locke's method is considered equivalent to Exact Fieller's method. Using the
This seems like a great challenge for you and Helmut, whose answers are always brilliant!
Dataset (xlxs-format)
In the Vasoconstrictor Assay guide published by the FDA in 1995, a small dataset of AUCE values for the test and reference drugs is provided. The purpose of this dataset is to serve as a numerical example for determining the bioequivalence of these two topical formulations (as part of the main study). At the end of the document, Locke's method is applied, yielding a 90% confidence interval of 53.6–165.9%.
I’ve read on this forum that Locke's method is considered equivalent to Exact Fieller's method. Using the
CI.RatioF() function and the dataset from the guide, I wonder if you could develop a function or script to calculate the Exact Fieller interval and match the result presented in the guide. Importantly, this should be done without directly using the formulas provided in the guide.This seems like a great challenge for you and Helmut, whose answers are always brilliant!
Dataset (xlxs-format)
Complete thread:
- how to construct confidence interval for un-transformed metric? lizhao 2016-02-17 19:01 [Power / Sample Size]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- how to construct confidence interval for un-transformed metric? jag009 2016-02-17 20:43
- how to construct confidence interval for un-transformed metric? mittyri 2016-02-17 22:34
- Fieller’s confidence interval Helmut 2016-02-18 13:38
- Fieller’s confidence interval lizhao 2016-02-22 20:20
- Fieller’s confidence interval yjlee168 2016-02-23 08:23
- Rescue approaching – PowerTOST d_labes 2016-02-23 09:08
- Rescue approaching – PowerTOSTWeidson 2024-11-28 23:15
- Why not base 🇷? Helmut 2024-12-03 13:39
- Why not base 🇷? Weidson 2025-02-15 20:42
- Why not base 🇷? Helmut 2024-12-03 13:39
- Rescue approaching – PowerTOSTWeidson 2024-11-28 23:15
- Fieller’s confidence interval lizhao 2016-02-22 20:20
- Fieller’s confidence interval Helmut 2016-02-18 13:38
Ing. Helmut Schütz