Bioequivalence and Bioavailability Forum

Dear d_labes/Helmut,

In the Vasoconstrictor Assay guide published by the FDA in 1995, a small dataset of AUCE values for the test and reference drugs is provided. The purpose of this dataset is to serve as a numerical example for determining the bioequivalence of these two topical formulations (as part of the main study). At the end of the document, Locke's method is applied, yielding a 90% confidence interval of 53.6–165.9%.
I’ve read on this forum that Locke's method is considered equivalent to Exact Fieller's method. Using the CI.RatioF() function and the dataset from the guide, I wonder if you could develop a function or script to calculate the Exact Fieller interval and match the result presented in the guide. Importantly, this should be done without directly using the formulas provided in the guide.
This seems like a great challenge for you and Helmut, whose answers are always brilliant!

Dataset (xlxs-format)