Bioequivalence and Bioavailability Forum

Balance… [Two-Stage / GS Designs]

posted by Helmut  – Vienna, Austria, 2024-03-12 12:40 (182 d 06:22 ago) – Posting: # 23903
Views: 2,003

Hi ElMaestro,

❝ Didn't they ask for imbalanced results?

Oh dear, no! 🤪
I never had to initiate the second stage so far… I power the first stage always in such a way that I get a reasonable high chance to show BE already. Small first stages are stupid.

For the protocol: If one prefers a belt plus suspenders, an -script to keep the pooled data set as balanced as possible.

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна! 
Helmut Schütz


The quality of responses received is directly proportional to the quality of the question asked. 🚮
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Complete thread:

• Two-Stage Sequential Potvin Designs BEQool 2024-03-04 08:45 [Two-Stage / GS Designs] 
  • TSD, GSD, Add-Ons, etc. Helmut 2024-03-05 13:56
  • Two-Stage Sequential Potvin Designs ElMaestro 2024-03-05 20:51
    • Two-Stage Sequential Potvin Designs BEQool 2024-03-10 10:11
      • Two-Stage Sequential Potvin Designs ElMaestro 2024-03-10 20:18
        • Too coarse grid? Helmut 2024-03-10 20:49
          • Too coarse grid? ElMaestro 2024-03-10 21:06
            • Balance…Helmut 2024-03-12 11:40
        • Two-Stage Sequential Potvin Designs BEQool 2024-03-11 20:45