Bioequivalence and Bioavailability Forum

Dear Detlew,
thank you for the answer. I had read the whole article but I am still not getting it
Partial replicate design is a crossover design so we can get S²_W (and consequently CV_W) and because R is replicated we can also get S²_WR (and consequently CV_WR).
So why cant we get S²_WT (and consequently CV_WT) from the following equation:
S²_W=(S²_WT+S²_WR)*2
as we only have one unknown (S²_WT)?

"There is an infinite number of combinations of CVwT- and CVwR- values giving the same pooled CVw. We simply don’t – and can’t – know the variance components.
It’s like asking a pupil “We added two numbers and their sum was five. What were the two numbers?” Leaves the pupil – rightly – dazed and confused."
--> Refering to this, if we know that the sum (S²_W) is 5 and one other number (S²_WR; lets say it is 3), we can get the unknown number (S²_WT; in this case we get 2)?

BEQool