homoscedasticity assumption in RSABE method [RSABE / ABEL]

posted by WinnieH – Sweden, 2023-08-18 10:57 (195 d 12:53 ago) – Posting: # 23697
Views: 1,279

Dear all,

I had a question related to the homoscedasticity assumption in the RSABE method when I read the tutorial of PowerTOST.
PowerTOST-RSABE

If the RSABE method is performed on the highly variable drug with the 4-way crossover design (not the NTI drug), is the homoscedasticity assumption always holden? And I think if a 3-way crossover design is used, there is no way to assume the homoscedasticity since the test drug is administered once and we can not calculate the WSV of the test drug.

A further question is, when do we assume the reference and test product have equal variances, i.e. CVwT ≡ CVwR? And why?

Thank you so much and looking forward to your reply!

Winnie


Edit: Category changed; see also this post #1[Helmut]

Complete thread:

UA Flag
Activity
 Admin contact
22,916 posts in 4,807 threads, 1,645 registered users;
33 visitors (0 registered, 33 guests [including 10 identified bots]).
Forum time: 22:51 CET (Europe/Vienna)

Nothing shocks me. I’m a scientist.    Harrison Ford (as Indiana Jones)

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5