Bioequivalence and Bioavailability Forum

Dear all,

I had a question related to the homoscedasticity assumption in the RSABE method when I read the tutorial of PowerTOST.
PowerTOST-RSABE

If the RSABE method is performed on the highly variable drug with the 4-way crossover design (not the NTI drug), is the homoscedasticity assumption always holden? And I think if a 3-way crossover design is used, there is no way to assume the homoscedasticity since the test drug is administered once and we can not calculate the WSV of the test drug.

A further question is, when do we assume the reference and test product have equal variances, i.e. CVwT ≡ CVwR? And why?

Thank you so much and looking forward to your reply!

Winnie

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Edit: Category changed; see also this post #1. [Helmut]