‘dlat’ for 3-period full replicate? [RSABE / ABEL]

posted by Helmut Homepage – Vienna, Austria, 2023-07-07 16:41 (86 d 14:55 ago) – Posting: # 23660
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Hi mittyri,

THX for discovering this gem!

I have a problem (both in Phoenix/WinNonlin, R, and – likely – in SAS as well). To calculate swR the FDA wants a linear model (in SAS-lingo proc glm) of repeated reference data with subject as a factor. However, in a 3-period full replicate they are all in one sequence and the model collapses. Now what?

If you want to play with data sets
  1. https://bebac.at/downloads/ds01.csv (TRTR|RTRT; the EMA’s reference data set I)
  2. https://bebac.at/downloads/ds03.csv (TRT|RTR; period 4 of #1 removed)

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