Bioequivalence and Bioavailability Forum • ‘dlat’ for 3-period full replicate?

‘dlat’ for 3-period full replicate? [RSABE / ABEL]

posted by Helmut – Vienna, Austria, 2023-07-07 16:41 (86 d 14:55 ago) – Posting: # 23660
Views: 891

Hi mittyri,

THX for discovering this gem!

I have a problem (both in Phoenix/WinNonlin, R, and – likely – in SAS as well). To calculate s_wR the FDA wants a linear model (in SAS-lingo proc glm) of repeated reference data with subject as a factor. However, in a 3-period full replicate they are all in one sequence and the model collapses. Now what?

If you want to play with data sets

https://bebac.at/downloads/ds01.csv (TRTR|RTRT; the EMA’s reference data set I)
https://bebac.at/downloads/ds03.csv (TRT|RTR; period 4 of #1 removed)

—
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Helmut Schütz

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Complete thread:

any SAS or R-macro for 3 period two sequence RSABEIs Achievwin 2023-07-05 18:38 [RSABE / ABEL]
- Use the one for TRTR | RTRT Helmut 2023-07-06 08:46
  - RSABE R coded by Detlew mittyri 2023-07-06 14:07
    - ‘dlat’ for 3-period full replicate?Helmut 2023-07-07 14:41
      - ‘dlat’ for 3-period full replicate? mittyri 2023-07-07 16:04
        
        Likely wrong workaround? Helmut 2023-07-07 20:06
        
        a bit corrected workaround mittyri 2023-07-07 22:52
        
        THX! Another attempt… Helmut 2023-07-08 12:15
        
        complete.cases for dlat and ilat? mittyri 2023-07-09 21:45
        
        a bit corrected workaround Achievwin 2023-07-10 20:43