Sample size for replicate crossover studies [Power / Sample Size]

posted by Helmut Homepage – Vienna, Austria, 2023-03-06 17:48 (405 d 19:15 ago) – Posting: # 23489
Views: 1,587

Hi Imph,

❝ For sample size calculation in the case of full replicate design using R software, when specifying the 2x2x4 in the script, do we get the same sample size whether the design is to be : TRTR|RTRT or TRRT|RTTR.


Yes. See there for the covered designs.

❝ And same question for the partially replicated design TRT|RTR vs TRR|RTT.


These are 3-period full replicate designs. See there for partial replicates.

❝ In the same way for manual computation, can we use the sample size formula presented by CHOW for the TRRT|RTTR design to calculate the sample size for TRTR|RTRT design. And same question, could the sample size formula of TRR|RTT design be used for TRT|RTR design.


Why are you still referring to Chow’s approximations full of typos? At least when you deal with reference-scaling you need simulations anyway. A formula does not – and cannot! – exist.

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