Bioequivalence and Bioavailability Forum

Hi,

For sample size calculation in the case of full replicate design using R software, when specifying the 2x2x4 in the script, do we get the same sample size whether the design is to be : TRTR|RTRT or TRRT|RTTR. And same question for the partially replicated design TRT|RTR vs TRR|RTT.

In the same way for manual computation, can we use the sample size formula presented by CHOW for the TRRT|RTTR design to calculate the sample size for TRTR|RTRT design. And same question, could the sample size formula of TRR|RTT design be used for TRT|RTR design.

Thanks a lot.