Sample size for 3-way crossover [Power / Sample Size]

posted by chrisk – 2022-08-10 17:24 (681 d 01:20 ago) – Posting: # 23211
Views: 5,183

Thanks again, Helmut, for sharing your wisdom so quickly and in details.

Since the alternative is based on T1 = R OR T2 = R, I am attempted to think that a larger sample size is required for the alternative T1 = R AND T2 = R. Is that indeed the case? If so, would you have any recommendation on how to approach the sample size estimation?

Thanks again, I very much appreciate your help!

Complete thread:

UA Flag
 Admin contact
23,059 posts in 4,841 threads, 1,665 registered users;
28 visitors (0 registered, 28 guests [including 7 identified bots]).
Forum time: 18:44 CEST (Europe/Vienna)

[…] an inappropriate study design is incapable of answering
a research question, no matter how careful the subsequent
methodology, conduct, analysis, and interpretation:
Flawless execution of a flawed design achieves nothing worthwhile.    J. Rick Turner

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz