Bioequivalence and Bioavailability Forum • true CV ≠ observed CV

true CV ≠ observed CV [Two-Stage / GS Designs]

posted by mittyri – Russia, 2022-06-27 19:22 (159 d 18:55 ago) – Posting: # 23097
Views: 853

Hi ElMaestro,

❝ Depends on the CV, but does not depend on the estimated CV. And that's a very significant difference. You never know anything other than your estimates, i.e. the knowledge that is generated as results of your trial do not determine the (maximum) type I error.

you are right, I completely agree. We cannot base TIE estimation on the observed CV.
As Helmut noted, to be on the safe side Potvin C should gone with the wind, so the framework per se should not permit such situations for given prerequisites (or even better to go with Inverse normal)

—
Kind regards,
Mittyri

Complete thread:

T1E after 1st stage in Power2Stage mittyri 2022-06-24 13:43 [Two-Stage / GS Designs]
- T1E after 1st stage in TSDs Helmut 2022-06-24 14:33
  - T1E after 1st stage in TSDs mittyri 2022-06-24 21:12
    - T1E after 1st stage in TSDs Helmut 2022-06-25 14:07
      - Potvin C consequences mittyri 2022-06-25 23:29
        
        Potvin C consequences ElMaestro 2022-06-26 09:11
        
        Potvin C consequences mittyri 2022-06-27 13:45
        
        Potvin C consequences Helmut 2022-06-27 14:49
        
        from Potvin C to Inverse Normal mittyri 2022-06-27 17:13
        
        From Potvin C to Inverse Normal: history (and outlook?) Helmut 2022-06-27 18:54
        
        Potvin C consequences ElMaestro 2022-06-27 17:13
        
        true CV ≠ observed CVmittyri 2022-06-27 17:22
- T1E after 1st stage in Power2Stage ElMaestro 2022-06-24 18:25
  - T1E after 1st stage in Power2Stage mittyri 2022-06-24 21:05
    - T1E after 1st stage in Power2Stage ElMaestro 2022-06-24 22:55