true CV ≠ observed CV [Two-Stage / GS Designs]

posted by mittyri – Russia, 2022-06-27 19:22 (520 d 01:32 ago) – Posting: # 23097
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Hi ElMaestro,

❝ Depends on the CV, but does not depend on the estimated CV. And that's a very significant difference. You never know anything other than your estimates, i.e. the knowledge that is generated as results of your trial do not determine the (maximum) type I error.

you are right, I completely agree. We cannot base TIE estimation on the observed CV.
As Helmut noted, to be on the safe side Potvin C should gone with the wind, so the framework per se should not permit such situations for given prerequisites (or even better to go with Inverse normal)

Kind regards,

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