true CV ≠ observed CV [Two-Stage / GS Designs]

posted by mittyri – Russia, 2022-06-27 17:22 (46 d 21:13 ago) – Posting: # 23097
Views: 630

Hi ElMaestro,

» Depends on the CV, but does not depend on the estimated CV. And that's a very significant difference. You never know anything other than your estimates, i.e. the knowledge that is generated as results of your trial do not determine the (maximum) type I error.

you are right, I completely agree. We cannot base TIE estimation on the observed CV.
As Helmut noted, to be on the safe side Potvin C should gone with the wind, so the framework per se should not permit such situations for given prerequisites (or even better to go with Inverse normal)

Kind regards,

Complete thread:

UA Flag
 Admin contact
22,301 posts in 4,667 threads, 1,585 registered users;
online 5 (0 registered, 5 guests [including 5 identified bots]).
Forum time: Saturday 14:36 CEST (Europe/Vienna)

In the field of observation,
chance favors only the mind that is prepared.    Louis Pasteur

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz