## Potvin C consequences [Two-Stage / GS Designs]

Hi ElMaestro,

some more questions

❝ Your type I error is not depending on your estimates and thus not depending on whether you went into stage 2 or not.

power.tsd(method = "C", CV = 0.2, n1 = 12, theta0 = 1.25) p(BE)    = 0.0511 power.tsd(method = "C", CV = 0.3, n1 = 12, theta0 = 1.25) p(BE)    = 0.043743

So T1E (OK, maximum type I error) depends on the CV, isn't it?
Or may be I misunderstood your point and we should not verify T1E during estimation process since we are assuming that the framework was stated as acceptable in the Protocol?

Kind regards,
Mittyri

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