Potvin C consequences [Two-Stage / GS Designs]

posted by mittyri – Russia, 2022-06-27 13:45 (47 d 01:12 ago) – Posting: # 23093
Views: 668

Hi ElMaestro,

some more questions

» Your type I error is not depending on your estimates and thus not depending on whether you went into stage 2 or not.

OK, what about this:
power.tsd(method = "C", CV = 0.2, n1 = 12, theta0 = 1.25)

p(BE)    = 0.0511

power.tsd(method = "C", CV = 0.3, n1 = 12, theta0 = 1.25)

p(BE)    = 0.043743


So T1E (OK, maximum type I error) depends on the CV, isn't it?
Or may be I misunderstood your point and we should not verify T1E during estimation process since we are assuming that the framework was stated as acceptable in the Protocol?

Kind regards,
Mittyri

Complete thread:

UA Flag
Activity
 Admin contact
22,301 posts in 4,667 threads, 1,585 registered users;
online 11 (0 registered, 11 guests [including 5 identified bots]).
Forum time: Saturday 14:57 CEST (Europe/Vienna)

In the field of observation,
chance favors only the mind that is prepared.    Louis Pasteur

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5