Output of sampleN.scABEL() - expanded limits ? [Power / Sample Size]

posted by d_labes  – Berlin, Germany, 2022-03-23 17:33 (309 d 18:57 ago) – Posting: # 22865
Views: 1,325

Dear Helmut,

❝ In coding the function sampleN.scABEL.ad() I tried to be more specific (see also my post below) and it gives for \(\small{CV_\textrm{wT}=CV_\textrm{wR}=0.3532}\):

Regulatory settings: EMA (ABEL)

Switching CVwR     : 0.3

Regulatory constant: 0.76

Expanded limits    : 0.7706 ... 1.2977

Upper scaling cap  : CVwR > 0.5

PE constraints     : 0.8000 ... 1.2500


The Expanded limits are only valid if the CV's are exactly the assumed ones.
They don't play any role during the simulations because the expansion applied depends on the CVwR of actual study, gradually different from study to study of the simulation.
That was the reason why the ugly programmer of the function sampleN.scABEL() abstain from giving that numbers :cool:.



Complete thread:

UA Flag
 Admin contact
22,477 posts in 4,708 threads, 1,603 registered users;
26 visitors (0 registered, 26 guests [including 11 identified bots]).
Forum time: 12:30 CET (Europe/Vienna)

In these matters the only certainty is
that nothing is certain.    Pliny the Elder

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz