Dose-dependent CV? [Power / Sample Size]

posted by Helmut Homepage – Vienna, Austria, 2022-01-23 15:46 (902 d 00:27 ago) – Posting: # 22744
Views: 1,831

Hi Imph,

❝ […] within subject coefficient of variation. Is it dose dependent?


If you have linear PK, generally yes. Otherwise, not necessarily.

❝ Can I take a coefficient of variation from a study done on a 500mg dosage and use it to calculate the number of subjects in a trial that will be done on a 1000mg dosage.


See above.

Dif-tor heh smusma 🖖🏼 Довге життя Україна! [image]
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

UA Flag
Activity
 Admin contact
23,099 posts in 4,857 threads, 1,646 registered users;
52 visitors (0 registered, 52 guests [including 6 identified bots]).
Forum time: 17:13 CEST (Europe/Vienna)

Imagine if every Thursday your shoes exploded
if you tied them the usual way.
This happens to us all the time with computers,
and nobody thinks of complaining.    Jef Raskin

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5