Dose-dependent CV? [Power / Sample Size]

posted by Helmut Homepage – Vienna, Austria, 2022-01-23 15:46 (376 d 01:10 ago) – Posting: # 22744
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Hi Imph,

❝ […] within subject coefficient of variation. Is it dose dependent?


If you have linear PK, generally yes. Otherwise, not necessarily.

❝ Can I take a coefficient of variation from a study done on a 500mg dosage and use it to calculate the number of subjects in a trial that will be done on a 1000mg dosage.


See above.

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