Bioequivalence and Bioavailability Forum

Hi Bebac_user,

» How can I calculate the intrasubject variability (CV) after my study was done ?
» Using MSE or (POE, U, L) ?

Both should work and both will give the same result within the meaning of rounding.

» I tried to compare them for Partially replicated study:
» CV for Cmax by MSE = 51.59%
» CV for Cmax by (POE, U, L) = 43.27%
» So, which one is the correct ?

Well, I think you may have made a tiny mistake somewhere since you did not get the same result. But I can't tell from your post where the hickup is.
Probably the MSE is the most direct method for getting a CV, but if the design was semirepl. then the intrasubject var. associated with ref might not have come from an MSE. It really depends on the steps you took. The devil is in the detail. So kindly provide more of it