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RegisterUchronia [RSABE / ABEL]
Dear Helmut!
Thank you for the prompt answer!
The reliability of someone else's data - that is the question (especially when one of the authors says "waouf"
As far as we (and the Agency) proclaim 25% to be clinically not relevant there is no difference in the rate of the harm for the customer's health independently from the a- or b- approach. For the b-approach he'll just receive not worser drug or doesn't receive it at all.
I try:
As CI is shifted to the right - does it mean that for these initial conditions the probability of the conclusion of HV is higher?
(By the way shouldn't we lower the degrees of freedom for the CV of the reference drug? 3*40-3 should correspond to the common CV of the Test and Reference, shouldn't it?)
Thank you for the prompt answer!
❝ The problem starts already here. How reliable is Oodendijk’s result? Is it the only one?
The reliability of someone else's data - that is the question (especially when one of the authors says "waouf"
❝ The crucial point is what we consider a “clinically not relevant \(\small{\Delta}\)”
As far as we (and the Agency) proclaim 25% to be clinically not relevant there is no difference in the rate of the harm for the customer's health independently from the a- or b- approach. For the b-approach he'll just receive not worser drug or doesn't receive it at all.
❝ Try the function CVCL() in PowerTOST.
I try:
library(PowerTOST)
CVCL(CV = 0.3, df = 3*40-4, side ="2-sided")
lower CL upper CL
0.2646219 0.3466708
As CI is shifted to the right - does it mean that for these initial conditions the probability of the conclusion of HV is higher?
(By the way shouldn't we lower the degrees of freedom for the CV of the reference drug? 3*40-3 should correspond to the common CV of the Test and Reference, shouldn't it?)
—
"Being in minority, even a minority of one, did not make you mad"
"Being in minority, even a minority of one, did not make you mad"
Complete thread:
- Inflated type I error with fixed widened limits? Helmut 2020-11-25 10:50 [RSABE / ABEL]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Inflated type I error with fixed widened limits? d_labes 2020-11-25 15:07
- Inflated type I error with fixed widened limits? Helmut 2020-11-26 00:09
- Inflated type I error with fixed widened limits d_labes 2020-11-26 15:38
- Inflated type I error: Not nice Helmut 2020-11-26 17:14
- Power of the GCC framework and power of PowerTOST d_labes 2020-11-28 11:20
- Sample sizes (ignoring the inflated TIE) Helmut 2020-11-29 11:21
- Power of the GCC framework and power of PowerTOST d_labes 2020-11-28 11:20
- Inflated type I error: Not nice Helmut 2020-11-26 17:14
- Inflated type I error with fixed widened limits d_labes 2020-11-26 15:38
- Inflated type I error with fixed widened limits? Helmut 2020-11-26 00:09
- Inflated type I error with fixed widened limits? wienui 2020-11-29 14:03
- Inflated type I error with fixed widened limits d_labes 2020-11-29 17:51
- Inflated type I error with fixed widened limits Helmut 2020-11-30 00:14
- Inflated type I error with fixed widened limits wienui 2020-11-30 03:30
- Houston, we have a problem! Helmut 2020-11-30 14:42
- Paradox of tolerance Astea 2020-12-01 23:34
- Οὐτοπεία ∨ Εὐτοπεία Helmut 2020-12-02 01:37
- UchroniaAstea 2020-12-02 09:46
- Steampunk Helmut 2020-12-02 11:34
- Dieselpunk Astea 2020-12-02 15:28
- Dieselpunk Helmut 2020-12-02 16:18
- Steampunk? OT d_labes 2020-12-02 19:30
- Steampunk? OT Astea 2020-12-02 19:58
- Dieselpunk Astea 2020-12-02 15:28
- Steampunk Helmut 2020-12-02 11:34
- UchroniaAstea 2020-12-02 09:46
- Οὐτοπεία ∨ Εὐτοπεία Helmut 2020-12-02 01:37
- Paradox of tolerance Astea 2020-12-01 23:34
- PowerTOST 1.5-2.9000 on GitHub Helmut 2020-12-23 12:18
- Houston, we have a problem! Helmut 2020-11-30 14:42
- Inflated type I error with fixed widened limits wienui 2020-11-30 03:30
- Inflated type I error with fixed widened limits Helmut 2020-11-30 00:14
- Inflated type I error with fixed widened limits d_labes 2020-11-29 17:51
- Inflated type I error with fixed widened limits? d_labes 2020-11-25 15:07
Ing. Helmut Schütz