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RegisterInflated type I error with fixed widened limits [RSABE / ABEL]
Dear Osama,
Imagine, you have a true CVwR of 30%. That means your true BE limits should be 80% ... 125%.
Now you performe a study but obtain an estimate of CVwR of 35%. Given this you use the widened (fixed) BE acceptance range of 75% ... 133.33%. With that acceptance range the BE decision is easier to obtain. This also happens if the true theta0 (GMR) is 125% (or 80%), i.e. bioinequivalence is what we have. Thus more than 5% of BE decision result, that means there is an alpha inflation.
Hope this makes sense to you.
May be Helmut has a better (paedogogical) explanation because he is an exceptionally gifted preacher
.
❝ ... how could this type I error inflation happen?
Imagine, you have a true CVwR of 30%. That means your true BE limits should be 80% ... 125%.
Now you performe a study but obtain an estimate of CVwR of 35%. Given this you use the widened (fixed) BE acceptance range of 75% ... 133.33%. With that acceptance range the BE decision is easier to obtain. This also happens if the true theta0 (GMR) is 125% (or 80%), i.e. bioinequivalence is what we have. Thus more than 5% of BE decision result, that means there is an alpha inflation.
Hope this makes sense to you.
May be Helmut has a better (paedogogical) explanation because he is an exceptionally gifted preacher
.—
Regards,
Detlew
Regards,
Detlew
Complete thread:
- Inflated type I error with fixed widened limits? Helmut 2020-11-25 10:50 [RSABE / ABEL]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Inflated type I error with fixed widened limits? d_labes 2020-11-25 15:07
- Inflated type I error with fixed widened limits? Helmut 2020-11-26 00:09
- Inflated type I error with fixed widened limits d_labes 2020-11-26 15:38
- Inflated type I error: Not nice Helmut 2020-11-26 17:14
- Power of the GCC framework and power of PowerTOST d_labes 2020-11-28 11:20
- Sample sizes (ignoring the inflated TIE) Helmut 2020-11-29 11:21
- Power of the GCC framework and power of PowerTOST d_labes 2020-11-28 11:20
- Inflated type I error: Not nice Helmut 2020-11-26 17:14
- Inflated type I error with fixed widened limits d_labes 2020-11-26 15:38
- Inflated type I error with fixed widened limits? Helmut 2020-11-26 00:09
- Inflated type I error with fixed widened limits? wienui 2020-11-29 14:03
- Inflated type I error with fixed widened limitsd_labes 2020-11-29 17:51
- Inflated type I error with fixed widened limits Helmut 2020-11-30 00:14
- Inflated type I error with fixed widened limits wienui 2020-11-30 03:30
- Houston, we have a problem! Helmut 2020-11-30 14:42
- Paradox of tolerance Astea 2020-12-01 23:34
- Οὐτοπεία ∨ Εὐτοπεία Helmut 2020-12-02 01:37
- Uchronia Astea 2020-12-02 09:46
- Steampunk Helmut 2020-12-02 11:34
- Dieselpunk Astea 2020-12-02 15:28
- Dieselpunk Helmut 2020-12-02 16:18
- Steampunk? OT d_labes 2020-12-02 19:30
- Steampunk? OT Astea 2020-12-02 19:58
- Dieselpunk Astea 2020-12-02 15:28
- Steampunk Helmut 2020-12-02 11:34
- Uchronia Astea 2020-12-02 09:46
- Οὐτοπεία ∨ Εὐτοπεία Helmut 2020-12-02 01:37
- Paradox of tolerance Astea 2020-12-01 23:34
- PowerTOST 1.5-2.9000 on GitHub Helmut 2020-12-23 12:18
- Houston, we have a problem! Helmut 2020-11-30 14:42
- Inflated type I error with fixed widened limits wienui 2020-11-30 03:30
- Inflated type I error with fixed widened limits Helmut 2020-11-30 00:14
- Inflated type I error with fixed widened limitsd_labes 2020-11-29 17:51
- Inflated type I error with fixed widened limits? d_labes 2020-11-25 15:07
Ing. Helmut Schütz