Inflated type I error: Not nice [RSABE / ABEL]
❝ ❝ Shit.
❝
❝ Why shit?
Cause it slipped through my attention for almost fifteen years… In South Africa for Cmax fixed limits of 75.00–133.33% may be used (no replicate design needed).
❝ ❝ ❝ Quick and dirty captured code from power.scABEL.sds.
❝ ❝
❝ ❝ How, did you do that? That’s beyond me.
❝
❝ Stolen the code of subject data sims and scaled ABE evaluation in the working horse function .pwr.SABE.sds()
.
❝ Have a look into the code of the new but undocumented function power.fwl.sds()
in the GitHub repository.
THX!
❝ ❝ ...And got 20.568% after eleven (!) hours.
❝ Wow! 11 hours for one number! 106 sims in ca. 4-5 sec with my implementation.
Mühsam ernährt sich das Eichhörnchen.
❝ Some results with setseed=FALSE
:
❝ power.fwl.sds(CV=0.3, n=40, theta0=0.8, design="2x2x4", setseed=F)
❝ 0.2045, 0.2066, 0.2047, 0.2051, 0.2082
❝ Seems we are simulating the same number .
Terrible for drugs which are not highly variable (reminds me on the FDA’s RSABE). The design is less important.
2-sequence 4-period (full) replicates
2-sequence 3-period (full) replicates
3-sequence 3-period (partial) replicates
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Complete thread:
- Inflated type I error with fixed widened limits? Helmut 2020-11-25 10:50 [RSABE / ABEL]
- Inflated type I error with fixed widened limits? d_labes 2020-11-25 15:07
- Inflated type I error with fixed widened limits? Helmut 2020-11-26 00:09
- Inflated type I error with fixed widened limits d_labes 2020-11-26 15:38
- Inflated type I error: Not niceHelmut 2020-11-26 17:14
- Power of the GCC framework and power of PowerTOST d_labes 2020-11-28 11:20
- Sample sizes (ignoring the inflated TIE) Helmut 2020-11-29 11:21
- Power of the GCC framework and power of PowerTOST d_labes 2020-11-28 11:20
- Inflated type I error: Not niceHelmut 2020-11-26 17:14
- Inflated type I error with fixed widened limits d_labes 2020-11-26 15:38
- Inflated type I error with fixed widened limits? Helmut 2020-11-26 00:09
- Inflated type I error with fixed widened limits? wienui 2020-11-29 14:03
- Inflated type I error with fixed widened limits d_labes 2020-11-29 17:51
- Inflated type I error with fixed widened limits Helmut 2020-11-30 00:14
- Inflated type I error with fixed widened limits wienui 2020-11-30 03:30
- Houston, we have a problem! Helmut 2020-11-30 14:42
- Paradox of tolerance Astea 2020-12-01 23:34
- Οὐτοπεία ∨ Εὐτοπεία Helmut 2020-12-02 01:37
- Uchronia Astea 2020-12-02 09:46
- Steampunk Helmut 2020-12-02 11:34
- Dieselpunk Astea 2020-12-02 15:28
- Dieselpunk Helmut 2020-12-02 16:18
- Steampunk? OT d_labes 2020-12-02 19:30
- Steampunk? OT Astea 2020-12-02 19:58
- Dieselpunk Astea 2020-12-02 15:28
- Steampunk Helmut 2020-12-02 11:34
- Uchronia Astea 2020-12-02 09:46
- Οὐτοπεία ∨ Εὐτοπεία Helmut 2020-12-02 01:37
- Paradox of tolerance Astea 2020-12-01 23:34
- PowerTOST 1.5-2.9000 on GitHub Helmut 2020-12-23 12:18
- Houston, we have a problem! Helmut 2020-11-30 14:42
- Inflated type I error with fixed widened limits wienui 2020-11-30 03:30
- Inflated type I error with fixed widened limits Helmut 2020-11-30 00:14
- Inflated type I error with fixed widened limits d_labes 2020-11-29 17:51
- Inflated type I error with fixed widened limits? d_labes 2020-11-25 15:07