Bioequivalence and Bioavailability Forum • Inflated type I error with fixed widened limits?

Inflated type I error with fixed widened limits? [RSABE / ABEL]

posted by d_labes – Berlin, Germany, 2020-11-25 16:07 (1687 d 10:14 ago) – Posting: # 22085
Views: 11,877

Dear Helmut,

❝ What happens if we pre-specify the widened acceptance range and discover in the study that CV_wR ≤30? Assess the study for the conventional AR of 80.00–125.00%? IMHO, that means we have a data-driven decision – which might be false and result in an inflated type I error.

Correct.

❝ I performed simulations acc. to my understanding of the GL:

❝

[image]

❝ CV_wR = CV_wT = 30%, balanced 4-period 2-sequence full replicate design (TRTR|RTRT), n = 40 (81% power for θ₀ = 0.90), 10⁶ studies with θ₀ = 1.25: ~20.6% passed…

Confirmed! At least in magnitude.
My result: 20.46% passed.
Quick and dirty captured code from power.scABEL.sds.

—
Regards,

Detlew

Complete thread:

Inflated type I error with fixed widened limits? Helmut 2020-11-25 10:50 [RSABE / ABEL]
- Inflated type I error with fixed widened limits?d_labes 2020-11-25 15:07
  - Inflated type I error with fixed widened limits? Helmut 2020-11-26 00:09
    - Inflated type I error with fixed widened limits d_labes 2020-11-26 15:38
      - Inflated type I error: Not nice Helmut 2020-11-26 17:14
        
        Power of the GCC framework and power of PowerTOST d_labes 2020-11-28 11:20
        
        Sample sizes (ignoring the inflated TIE) Helmut 2020-11-29 11:21
        
        Bug? d_labes 2020-11-29 16:22
        
        “Feature” Helmut 2020-11-30 00:16
- Inflated type I error with fixed widened limits? wienui 2020-11-29 14:03
  - Inflated type I error with fixed widened limits d_labes 2020-11-29 17:51
    - Inflated type I error with fixed widened limits Helmut 2020-11-30 00:14
      - Inflated type I error with fixed widened limits wienui 2020-11-30 03:30
        
        Houston, we have a problem! Helmut 2020-11-30 14:42
        
        Paradox of tolerance Astea 2020-12-01 23:34
        
        Οὐτοπεία ∨ Εὐτοπεία Helmut 2020-12-02 01:37
        
        Uchronia Astea 2020-12-02 09:46
        
        Steampunk Helmut 2020-12-02 11:34
        
        Dieselpunk Astea 2020-12-02 15:28
        
        Dieselpunk Helmut 2020-12-02 16:18
        
        Steampunk? OT d_labes 2020-12-02 19:30
        
        Steampunk? OT Astea 2020-12-02 19:58
        
        PowerTOST 1.5-2.9000 on GitHub Helmut 2020-12-23 12:18