Multiple dose design Sample size [Power / Sample Size]

posted by Researcher101 – Egypt, 2020-10-14 11:37 (11 d 01:26 ago) – Posting: # 22000
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(edited by on 2020-10-19 08:41)

Also if Cmax ss within variability is around 20 % and Cmin ss within variability is around 41 % on which one should I depend


Dears, I am asking about the factor we determine the sample size in multiple dose studies? Should I estimate sample size based on intra subject variability of Cmin or Cmax or C tau?

Can I pool the CVs to estimate sample size?


Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post #5! [Ohlbe]

Edit: Post merged with a new (deleted) post of 2020-10-19. Relax; see also this post #9[Helmut]

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