CV of Css,max ≤ CV of Cmax [Power / Sample Size]

posted by Helmut Homepage – Vienna, Austria, 2020-10-14 13:27 (1726 d 12:20 ago) – Posting: # 21999
Views: 3,909

Hi Researcher101,

if you have the CV of Cmax from a MD study that’s best, of course.

❝ Also is it in the safe side to estimate sample size based on Cmax single dose not multiple dose?


Yes, since generally (I know only one published exception*) variability in steady state is ≤ the one after a single dose.



Dif-tor heh smusma 🖖🏼 Довге життя Україна! [image]
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

UA Flag
Activity
 Admin contact
23,427 posts in 4,929 threads, 1,679 registered users;
32 visitors (0 registered, 32 guests [including 8 identified bots]).
Forum time: 01:48 CEST (Europe/Vienna)

Many people tend to look at programming styles and languages like religions:
if you belong to one, you cannot belong to others.
But this analogy is another fallacy.    Niklaus Wirth

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5