CV of Css,max ≤ CV of Cmax [Power / Sample Size]

posted by Helmut Homepage – Vienna, Austria, 2020-10-14 13:27 (1141 d 07:02 ago) – Posting: # 21999
Views: 1,885

Hi Researcher101,

if you have the CV of Cmax from a MD study that’s best, of course.

❝ Also is it in the safe side to estimate sample size based on Cmax single dose not multiple dose?


Yes, since generally (I know only one published exception*) variability in steady state is ≤ the one after a single dose.



Dif-tor heh smusma 🖖🏼 Довге життя Україна! [image]
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

UA Flag
Activity
 Admin contact
22,811 posts in 4,783 threads, 1,639 registered users;
23 visitors (0 registered, 23 guests [including 7 identified bots]).
Forum time: 19:30 CET (Europe/Vienna)

Every man gets a narrower and narrower field of knowledge
in which he must be an expert in order to compete with other people.
The specialist knows more and more about less and less
and finally knows everything about nothing.    Konrad Lorenz

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5