CV of Css,max ≤ CV of Cmax [Power / Sample Size]

posted by Helmut Homepage – Vienna, Austria, 2020-10-14 13:27 (1377 d 14:48 ago) – Posting: # 21999
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Hi Researcher101,

if you have the CV of Cmax from a MD study that’s best, of course.

❝ Also is it in the safe side to estimate sample size based on Cmax single dose not multiple dose?


Yes, since generally (I know only one published exception*) variability in steady state is ≤ the one after a single dose.



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