CV of Css,max ≤ CV of Cmax [Power / Sample Size]

posted by Helmut Homepage – Vienna, Austria, 2020-10-14 11:27 (188 d 16:20 ago) – Posting: # 21999
Views: 669

Hi Researcher101,

if you have the CV of Cmax from a MD study that’s best, of course.

» Also is it in the safe side to estimate sample size based on Cmax single dose not multiple dose?

Yes, since generally (I know only one published exception*) variability in steady state is ≤ the one after a single dose.

Dif-tor heh smusma 🖖
Helmut Schütz

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

 Admin contact
21,419 posts in 4,475 threads, 1,510 registered users;
online 11 (0 registered, 11 guests [including 1 identified bots]).
Forum time: Wednesday 03:48 CEST (Europe/Vienna)

In the Middles Ages the lingua franca of science was Latin.
Nowadays the language of science is bad English.    Anonymous

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz